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Silyl Modification of Biologically Active Compounds. 7. Synthesis, Structure, Physicochemical and Biological Properties of Some Silicon-containing “3+1” Oxorhenium(V) Complexes

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

With the aim of studying the structure-physicochemical properties-biological activity relation, we have synthesized a series of organosilicon neutral oxorhenium(V) complexes with mixed ligands and we have determined their lipophilicity. X-ray diffraction has been used to establish the molecular structure of (3-triphenylsiloxypropanethiolato)(3-thiapentane-1,5-dithiolato)oxorhenium(V), (2-trimethylsiloxy- and 2-hydroxyethanethiolato)[3-(N-methyl)azapentane-1,5-dithiolato]oxorhenium(V). We have studied the neurotropic properties and acute toxicity of the synthesized complexes in vivo and their dependence on the nature of the monodentate and tridentate ligands. We have established that all the studied compounds have pronounced sedative action (they prolong the life of mice under hypoxia conditions, they are phenamine antagonists, they exhibit anticonvulsive action and prevent retrograde amnesia).

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REFERENCES

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, Riga, LV-1006

    A. Zablotskaya, I. Segal, A. Kemme, S. Germane, J. Popelis & E. Lukevics

  2. Forschungszentrum Rossendorf [Rossendorf Research Cente, PO Box 51 01 19, Dresden, D-01314, Germany

    R. Berger (PO Box 51 01 19, Dresden D-01314, Germany) & H. Spies (PO Box 51 01 19, Dresden D-01314, Germany)

Authors
  1. A. Zablotskaya
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  2. I. Segal
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  3. A. Kemme
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  4. S. Germane
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  5. J. Popelis
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  6. E. Lukevics
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  7. R. Berger
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  8. H. Spies
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Zablotskaya, A., Segal, I., Kemme, A. et al. Silyl Modification of Biologically Active Compounds. 7. Synthesis, Structure, Physicochemical and Biological Properties of Some Silicon-containing “3+1” Oxorhenium(V) Complexes. Chemistry of Heterocyclic Compounds 38, 477–489 (2002). https://doi.org/10.1023/A:1016095625279

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  • DOI: https://doi.org/10.1023/A:1016095625279

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