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Determination of Tablet Coating Distribution by Deconvolution of Uncoated and Coated Tablet Weight Distributions

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Abstract

Purpose. The purpose of this research is to obtain the tablet coating distribution from weight distributions of uncoated and coated tablets.

Methods. The method of deconvolution with digital smoothing was used to calculate the distribution of coating applied to a tablet population from separate random measurements of individual uncoated and coated tablets.

Results. It was demonstrated that the calculated coating weight distribution agrees well with the measured distribution. The effect of the smoothing factor on the solution is illustrated.

Conclusions. This method can be used during development to facilitate process scale-up/optimization. In routine production, the method can assess the reproducibility and consistency of a coating process.

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REFERENCES

  1. J. J. Harrison, I. Lafferty, W. D. Moore, D. A. Rawlins, N. R. Rissen and P. M. Thwaites. Titanium Determination as a Method of Quantifying Film Coat Application on to Tablets. Drug Dev. Ind. Pharm. 17:149–155 (1991).

    Google Scholar 

  2. S. C. Porter and K. Saraceni. Opportunities for Cost Containment in Aqueous Film Coating. Pharm. Tech. 12:62–76 (1988).

    Google Scholar 

  3. G. L. Fourman, C. W. Hines and R. S. Hritsko. Assessing the Uniformity of Aqueous Film Coating Applied to Compressed Tablets. Pharm. Tech. 19:70–76 (1995).

    Google Scholar 

  4. P. L. Mills and M. P. Duduković. Deconvolution of Noisy Tracer Response Data by a Linear Filtering Method. AIChE Journal, 34:1752–1756 (1988).

    Google Scholar 

  5. P. A. Jansson. Deconvolution with Application in Spectroscopy, Academic Press, Orlando, 1984.

    Google Scholar 

  6. B. R. Hunt. Biased Estimation for Nonparametric Identification of Linear Systems. Math. Biosci. 10:215–237 (1971).

    Google Scholar 

  7. IMSL. MATH/LIBRARY, FORTRAN Subroutines for Mathematical Application, ver.1.1, Houston, TX (1990).

  8. M. M. Desu and D. Raghavarao. Sample Size Methodology, Academic Press, Orlando, 1990.

    Google Scholar 

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Authors and Affiliations

  1. Abbott Laboratories, D-49D, 1401 Sheridan Rd, North Chicago, Illinois, 60064-4000

    Ji Zhou, Todd Williams, Herman Swopes & Thomas Hale

Authors
  1. Ji Zhou
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  2. Todd Williams
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  3. Herman Swopes
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  4. Thomas Hale
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Zhou, J., Williams, T., Swopes, H. et al. Determination of Tablet Coating Distribution by Deconvolution of Uncoated and Coated Tablet Weight Distributions. Pharm Res 13, 381–386 (1996). https://doi.org/10.1023/A:1016036408155

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  • DOI: https://doi.org/10.1023/A:1016036408155

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