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The Determination of Microscopic lonization Constants of a Substituted Piperazine Using Estimates from Model Compounds

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Abstract

The microscopic ionization constants of l-[3-(4-chlorophenyl)propyl] piperazine (I) were determined using piperazine (P) and l,4-bis[3-(4-chlorophenyl)propyl] piperazine (II) as models for one of the ionizations. The macroscopic ionization constants for all three compounds were measured potentiometrically, and the micro constants of P and II, which are symmetrical molecules, were calculated from their macro constants. Only one micro constant of either P or II was suitable as a model for elucidating the micro constants of I.

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REFERENCES

  1. A. Albert and E. P. Sergeant. The Determination of Ionization Constants, 3rd ed., Chapman and Hall, New York, 1984.

    Google Scholar 

  2. R. F. Cookson. Chem. Rev. 74:5–28 (1974).

    Google Scholar 

  3. L. Z. Benet and J. E. Goyan. J. Pharm. Sci. 56:665–680 (1967).

    Google Scholar 

  4. A. P. Izerman, Bultsma, H. Timmerman, and J. Zaagsma. J. Pharm. Pharmacol. 36:11–15 (1984).

    Google Scholar 

  5. B. Quintero, J. Lopez, and J. Thomas. J. Pharm. Sci. 74:72–75 (1985).

    Google Scholar 

  6. R. B. Barlow and K. N. Burston. Br. J. Pharmacol. 69:587–595 (1980).

    Google Scholar 

  7. R. B. Barlow. Br. J. Pharmacol. 75:503–512 (1982).

    Google Scholar 

  8. A. Bryson, N. R. Davies, and E. P. Sergeant. J. Am. Chem. Soc. 85:1933–1938 (1963).

    Google Scholar 

  9. P. Vetesnik, J. Kavalek, and V. Beranek. Coll. Czechoslov. Chem. Commun. 36:2486–2499 (1971).

    Google Scholar 

  10. J. N. Butler. Ionic Equilibrium—A Mathematical Approach. Addison-Wesley, Reading, Mass., 1964.

    Google Scholar 

  11. P. S. Albright and L. J. Gosting. J. Am. Chem. Soc. 68:1061–1063 (1946).

    Google Scholar 

  12. K. C. Ong, R. A. Robinson, and R. G. Bates. Anal. Chem. 36:1971–1972 (1964).

    Google Scholar 

  13. D. W. Newton, W. J. Murray, and M. W. Lovell. J. Pharm. Sci. 71:1363–1366 (1982).

    Google Scholar 

  14. D. D. Perrin. In S. H. Yalkowsky, A. A. Sinkula, and S. C. Valvani (eds.), Physical Chemical Properties of Drugs, Marcel Dekker, New York, 1980.

    Google Scholar 

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Authors and Affiliations

  1. Pharmaceutics Department, Boehringer Ingelheim Pharmaceuticals, Inc, 90 East Ridge, P.O. Box 368, Ridgefield, Connecticut, 06877

    Nivedita K. Pandit

  2. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, 66044

    John M. Sisco

Authors
  1. Nivedita K. Pandit
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  2. John M. Sisco
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Pandit, N.K., Sisco, J.M. The Determination of Microscopic lonization Constants of a Substituted Piperazine Using Estimates from Model Compounds. Pharm Res 6, 177–181 (1989). https://doi.org/10.1023/A:1015944912736

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  • DOI: https://doi.org/10.1023/A:1015944912736

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