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The Relationship of pK a and Acute Skin Irritation in Man

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Abstract

The relationship between pK a and skin irritation in man is studied for a homologous series of benzoic acid derivatives, which permeate through human skin at comparable rates (15–88 µg/cm2/hr). Skin irritation and pK a are correlated for pK a ≤ 4. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to pK a, erythema at 24 hr appears to be the most sensitive parameter to variation in pK a when pK a ≤ 4.

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Authors and Affiliations

  1. CIBA-GEIGY, 444 Saw Mill River Road, Ardsley, New York, 10502

    Bret Berner, Gerard C. Mazzenga & Frank H. Clarke

  2. Department of Dermatology, University of California Medical School, San Francisco, California, 94143

    Donald R. Wilson & Howard I. Maibach

  3. Department of Pharmacy and Pharmaceutical Chemistry, University of California, San Francisco, California, 94143

    Richard H. Guy

Authors
  1. Bret Berner
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  2. Donald R. Wilson
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  3. Richard H. Guy
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  4. Gerard C. Mazzenga
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  5. Frank H. Clarke
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  6. Howard I. Maibach
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Berner, B., Wilson, D.R., Guy, R.H. et al. The Relationship of pK a and Acute Skin Irritation in Man. Pharm Res 5, 660–663 (1988). https://doi.org/10.1023/A:1015931105660

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  • DOI: https://doi.org/10.1023/A:1015931105660

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