Skip to main content
SpringerLink
Log in

Intrinsic Dissolution Rates of Tablet Filler-Binders and Their Influence on the Dissolution of Drugs from Tablet Formulations

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

Abstract

Intrinsic dissolution rates were determined for different grades of commonly used calcium salt fillers and lactose. Typical tablet formulations of low-dose drugs were studied to determine the influence of this property on drug dissolution.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. A. D. Koparkar. The Modification of an Automated Dissolution Test Apparatus for the Rotating Disk Method of Intrinsic Dissolution Rate Measurement, Its Validation and Use in Evaluating Tablet Diluents, Ph.D. dissertation, University of Maryland, Baltimore, 1983.

  2. D. P. Gregory and A. C. Riddiford. J. Chem. Soc. Lond. 3:3756 (1956).

    Google Scholar 

  3. Pharmacopoeia Helvetica, 6th ed., Pharmacopoekommission, Bern, Switzerland, 1971.

  4. British Pharmacopoeia, Her Majesty's Stationery Office at the University Press, London, 1980.

  5. United States Pharmacopeia, 21st revision, United States Pharmacopeial Convention, Rockville, Md., 1985.

  6. K. Diem and C. Lentner (eds.). Scientific Tables, 7th ed., Documenta Geigy, Ardsley, N.Y. 1970, p. 176.

    Google Scholar 

  7. K. Diem and C. Lentner (eds.). Scientific Tables, 7th ed., Documenta Geigy, Ardsley, N.Y. 1970, p. 648.

    Google Scholar 

  8. Remington's Pharmaceutical Sciences, 15th ed., Mack, Easton, Pa., 1975.

  9. L. L. Augsburger, Dissolution of Thiazides, Final Technical Report, RFP 223-76-3009, F.D.A., Health and Human Services, Washington, D.C.

Download references

Author information

Authors and Affiliations

  1. CIBA-GEIGY Corporation, Building W, 556 Morris Avenue, Summit, New Jersey, 07901

    Arun D. Koparkar

  2. School of Pharmacy, University of Maryland, Baltimore, Maryland, 21201

    Larry L. Augsburger & Ralph F. Shangraw

Authors
  1. Arun D. Koparkar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Larry L. Augsburger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ralph F. Shangraw
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Koparkar, A.D., Augsburger, L.L. & Shangraw, R.F. Intrinsic Dissolution Rates of Tablet Filler-Binders and Their Influence on the Dissolution of Drugs from Tablet Formulations. Pharm Res 7, 80–86 (1990). https://doi.org/10.1023/A:1015895827989

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1015895827989

Search

Navigation