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Microbial Production of a Crisnatol Metabolite

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Abstract

Microbial metabolism studies of crisnatol (1), a new DNA interca-lator, has resulted in the isolation and characterization of a major metabolite identified as the C-l hydroxylated crisnatol (2). The structure of the metabolite was established by comparison of its spectral data to that of crisnatol. Complete 13C-NMR assignments for crisnatol and its C-l hydroxylated metabolite were also made.

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Authors and Affiliations

  1. Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677

    Charles D. Hufford, Saleh H. El-Sharkawy, Tannis M. Jurgens & Julie R. Mikell

  2. Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677

    Charles D. Hufford

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  1. Charles D. Hufford
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  2. Saleh H. El-Sharkawy
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  3. Tannis M. Jurgens
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  4. Julie R. Mikell
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Hufford, C.D., El-Sharkawy, S.H., Jurgens, T.M. et al. Microbial Production of a Crisnatol Metabolite. Pharm Res 9, 623–625 (1992). https://doi.org/10.1023/A:1015893808830

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