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Disposition of Bismuth in the Rat. II. Pharmacokinetics and Biliary Excretion

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Abstract

The pharmacokinetics and biliary excretion profile of intravenously administered bismuth ions were investigated in male Sprague Dawley rats. The data indicated that in the dose range studied, the percentage of dose excreted in urine ranged from 58 to 63%. The mean residence time for bismuth ions was 3.93, 4.07, and 5.45 hr for the 0.5, 0.75, and 1.0 mg/kg dose, respectively, while the volume of distribution at steady state was 0.75, 1.24, and 1.38 L/kg for the three doses. Blood clearance values ranged from 0.2 to 0.32 L/hr/kg. Blood bismuth ion concentrations toward the latter part of the sampling schedule indicated significant variability. The bile-to-blood concentration ratio of intravenously administered bismuth exceeded 1.0 for the three doses studied, suggesting that transport of bismuth from blood to bile may be carrier mediated.

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Authors and Affiliations

  1. Marion Merrel Dow, P.O. Box 9627, Park B, Kansas City, Missouri, 64134

    Niranjan Rao

  2. Department of Pharmaceutics, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, Texas, 77030

    Stuart Feldman

Authors
  1. Niranjan Rao
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  2. Stuart Feldman
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Rao, N., Feldman, S. Disposition of Bismuth in the Rat. II. Pharmacokinetics and Biliary Excretion. Pharm Res 7, 237–241 (1990). https://doi.org/10.1023/A:1015813826597

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  • DOI: https://doi.org/10.1023/A:1015813826597

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