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Life Is the Existence, Interaction (Functioning), and Reproduction of Unique, Highly Organized Nucleotide and Amino Acid Consequences

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Abstract

The most recent achievements in molecular endocrinology concerning mechanisms of molecular regulation of gene expression are discussed. The author's concept is presented about probable trends in the field of study of the programs of individual development of living organism, coded in the genome.

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REFERENCES

  1. Ing, N.H. and O™Malley, B.W., The Steroid Hormone Receptor Superfamily: Molecular Mechanism of Action, Molecular Endocrinology, Weintraub, B.D., Ed., New York: Raven Press Ltd., 1995, pp. 195–216.

    Google Scholar 

  2. Williams, G.R. and Brent, G.A., Thyroid Hormone Response Elements, Molecular Endocrinology, Weintraub, B.D., Ed., New York: Raven Press Ltd., 1995, pp. 217–240.

    Google Scholar 

  3. Umesono, K. and Evans, R.M., Determination of Target Gene Specificity for Steroid/Thyroid Hormone Receptors, Cell, 1989, vol. 57, pp. 1139– 1146.

    Google Scholar 

  4. Montegue, W., The Role of Cyclic Nucleotide in Hormone Action, The Biochemistry of Polypeptide Hormones, Valles, V., Howell, S.L., and Taylor, K.W., Eds., Chichester: A WilleyŠInterscience Publication, John Willey and Sons, 1985, pp. 390–409.

    Google Scholar 

  5. Lomasney, J.W., Allen, L.F., and Lefkowitz, R.J., Cloning and Regulation of Catecholamine Receptor Genes, Molecular Endocrinology, Weintraub, B.D., Ed., New York: Raven Press Ltd., 1995, pp. 115–131.

    Google Scholar 

  6. Kohn, L.D., Ban, T., Okajima, F., et al., Cloning and Regulation of Glycoprotein Hormone Receptor Genes, Molecular Endocrinology, Weintraub, B.D., Ed., New York: Raven Press Ltd., 1995, pp. 133–153.

    Google Scholar 

  7. Pestell, R.G. and Jameson, J.L., Transcri ptional Regulation of Endocrine Genes by Second-Messenger Signaling Pathways, Molecular Endocrinology, Weintraub, B.D., Ed., New York: Raven Press Ltd., 1995, pp. 59–76.

    Google Scholar 

  8. Montminy, M.R., Sevarino, K.A., Wagner, J.A., et al., Identification of a Cyclic-AMP-responsive Element within the Rat Somatostatin Gene, Proc. Natl Acad. Sci. USA, 1986, vol. 83, pp. 6682– 6686.

    Google Scholar 

  9. Deutsch, P.J., Jameson, J.L., and Habener, K.A., Cyclic AMP Responsiveness of Human Glycoprotein-Alpha Gene Transcri ption Is Directed by a Repeated 18-Base Pair Enhancer. Alpha-Promoter Receptivity to the Enhancer Confers Cell Preferential Expression, J. Biol. Chem., 1987, vol. 262, pp. 12 169–12 174.

    Google Scholar 

  10. Delegeane, A.M., Ferland, L.Y., and Mellon, P.L., Tissue-Specific Enhancer of Human Glycoprotein Hormone a-Subunit Gene: Dependence on Cyclic AMP-Inducible Elements, Mol. Cell. Biol., 1987, vol. 7, pp. 3994–4002.

    Google Scholar 

  11. Silver, B.J., Bakar, J.A., Virgin, J.B., et al., Cyclic AMP Regulation of Human Glycoprotein Hormone Alpha-Subunit Gene Is Edited by an 18-BasePair Element, Proc. Natl Acad. Sci. USA, 1987, vol. 84, pp. 2198–2202.

    Google Scholar 

  12. Tsukada, T., Fink, J.S., and Mandel, G., et al., Identification of a Region in Human Vasoactive Intestinal Polypeptide Gene Responsible for Regulation by Cyclic AMP, J. Biol. Chem., 1987, vol. 262, pp. 8743–8747.

    Google Scholar 

  13. Comb, M., Birnberg, N.C., Seasholdtz, A., et al., A Cyclic AMPand Phorbol Ester-Inducible DNA Element, Nature, 1986, vol. 323, pp. 353–356.

    Google Scholar 

  14. Albanese, C., Kay, T.W.H., Troccoli, N.M., et al., Novel Cyclic Adenosine 3',5'-Monophosphate Response Element 9n Human Chorionic Gonadotropin b-Subunit Gene, Mol. Endocrinol., 1991, vol. 5, pp. 693–702.

    Google Scholar 

  15. Kurten, R.C., Levy, L.O., Dshey, J., et al., Identification and Characterization of the GC-Rich Cyclic Adenosine 3',5'-Monophosphate (cAMP)ŠInducible Promoter of Type IIB cAMP-Dependent Protein Kinase Regulatory Subunit Gene, Mol. Endocrinol., 1992, vol. 6, pp. 537–549.

    Google Scholar 

  16. Robinson-Steiner, A.M. and Corbin, J.D., Probable Involvement of Both Intrachain cAMP Binding Sites in Activation of Protein Kinase, J. Biol. Chem., 1983, vol. 258, pp. 1032–1039.

    Google Scholar 

  17. DeCrombrugghe, B., Busby, S., and Buc, H., cAMP Receptor Protein: Role in Transcri ption Activation, Science, 1984, vol. 224, pp. 831–838.

    Google Scholar 

  18. Wilks, A.F., Harper, A.G., Kubrin, R.R., et al., Two Novel Proteintyrosine Kinases, Each with a Second Phosphotransferase-Related Catalytic Domain, Define a New Class of Protein Kinase, Mol. Cell. Biol., 1991, vol. 11, pp. 2057–2065.

    Google Scholar 

  19. Harper, A.G., Andres, A.-C., Ziemiecki, A., et al., Jak2, a Third Member of Jak Family of Protein Tyrosine Kinases, Oncogene, 1992, vol. 7, pp. 1347–1353.

    Google Scholar 

  20. Ihle, J.N., Signaling By the Cytokine Receptor Superfamily. Just Another Kinase Story, Trends Endocrinol. Metab., 1994, vol. 5, pp. 137–143.

    Google Scholar 

  21. Ihle, J.N., Witthuhn, B.A., Quelle, F.W., et al., Signaling by the Cytokine Receptor Superfamily: Jaks and Stats, Trends Biochem. Sci., 1994, vol. 19, pp. 222–227.

    Google Scholar 

  22. Bole-Feysot, C., Goffin, V., Edery, M., et al., Prolactin (PRL) and Its Receptor: Action, Signal Transduction Pathways, and Phenotypes Observed in PRL Receptor Knockout Mice, Endocrinol. Rev., 1998, vol. 19, pp. 225–268.

    Google Scholar 

  23. Ihle, J.N., STATs: Signal Transducers and Activators of Transcri ption, Cell, 1996, vol. 84, pp. 331–334.

    Google Scholar 

  24. Zang, Y., Proenca, R., Maffey, M., et al., Position Cloning of the Mouse Obese Gene and Its Human Homologue, Nature, 1994, vol. 372, pp. 425–432.

    Google Scholar 

  25. Pankov, Yu.A., The ob Protein as a Product of Obese Gene Expression and Some Aspects of the Development of Modern Endocrinology: A Review, Biochemistry (Moscow), 1996, vol. 61, pp. 705–710.

    Google Scholar 

  26. Pankov, Yu.A., Hormones as Life Regulators in the Current Molecular Endocrinology, Biochemistry (Moscow), 1998, vol. 63, pp. 1361–1373.

    Google Scholar 

  27. Lee, G.H., Proenca, R., Montes, J.M., et al., Abnormal Spicing of the Leptin Receptor in Diabetic Mice, Nature, 1996, vol. 379, pp. 632–635.

    Google Scholar 

  28. Montague, I.S., Farooqi, J.P., Whitehead, M.A., et al., Congenital Leptin Deficiency Is Associated with Severe Early-Onset Obesity, Nature, 1997, vol. 387, pp. 903–908.

    Google Scholar 

  29. Strobel, A., Issad, T., Camoin, L., et al., A Leptin Missense Mutation Is Associated with Hypogonadism and Morbid Obesity, Nature Gen., 1998, vol. 18, pp. 213–215.

    Google Scholar 

  30. Clement, K., Vaisse, N., Lahlou, S., et al., A Mutation in Human Leptin Receptor Gene Causes Obesity and Pituitary Dysfunction, Nature, 1998, vol. 392, pp. 398–340.

    Google Scholar 

  31. Pankov, Yu.A., Life as the Existence and Reproduction of Ordered Nucleotide and Amino Acid Sequences, with Special Consideration of Protein Hormones and Their Genes, Sov. Med. Rev. B. Physiochemical Aspects of Med., Harwood Academic Publishers GmbH, United Kingdom, 1991, vol. 2, pp. 109–145.

    Google Scholar 

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Pankov, Y.A. Life Is the Existence, Interaction (Functioning), and Reproduction of Unique, Highly Organized Nucleotide and Amino Acid Consequences. Journal of Evolutionary Biochemistry and Physiology 37, 576–581 (2001). https://doi.org/10.1023/A:1014047016727

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