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Synthesis of 1,3-Bis[3-X-2-(X-acetoxy)propyl]-6-methyl- 1,2,3,4-tetrahydropyrimidine-2,4-diones

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Abstract

A procedure was developed for synthesizing nitrogen-and-sulfur-containing pyrimidine derivatives by reactions of 1,3-bis(3-chloro-2-hydroxypropyl)-6-methyluracil with 1-butanethiol and chloroacetyl chloride, followed by treatment of the resulting 1,3-bis[3-chloro-2-(chloroacetoxy)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione with 1-butanethiol, morpholine, and piperidine. Oxidation of the sulfur-containing products with NaIO4 gave the corresponding sulfoxides.

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Authors and Affiliations

  1. Russian Academy of Sciences, Institute of Organic Chemistry, Ufa Research Center, pr. Oktyabrya 71, Ufa, 450054, Bashkortostan, Russia

    V. P. Krivonogov, G. A. Sivkova, Yu. I. Murinov, G. G. Kozlova, I. B. Abdrakhmanov', L. V. Spirikhin, N. G. Afzaletdinova & R. A. Khisamutdinov

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  1. V. P. Krivonogov
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  2. G. A. Sivkova
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  3. Yu. I. Murinov
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  4. G. G. Kozlova
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  5. I. B. Abdrakhmanov'
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  6. L. V. Spirikhin
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  7. N. G. Afzaletdinova
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  8. R. A. Khisamutdinov
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Krivonogov, V.P., Sivkova, G.A., Murinov, Y.I. et al. Synthesis of 1,3-Bis[3-X-2-(X-acetoxy)propyl]-6-methyl- 1,2,3,4-tetrahydropyrimidine-2,4-diones. Russian Journal of Organic Chemistry 37, 1786–1790 (2001). https://doi.org/10.1023/A:1013951329680

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  • DOI: https://doi.org/10.1023/A:1013951329680

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