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Dynamics of NADPH Diaphorase Activity in Raphe Neurons during Chronic Treatment with Opiates

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Abstract

Systemic administration of diacetylmorphine considerably reduced the number of NADPH diaphorase-positive (NO-synthesizing) neurons in rat brain raphe nuclei. This effect was blocked by naloxone. In animals with the withdrawal syndrome NO-ergic activity in raphe neurons increased and surpassed the normal.

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Authors and Affiliations

  1. Laboratory of Pharmacology, Institute of Sea Biology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok

    I. V. Dyuizen, P. A. Motavkin & V. V. Shorin

  2. Department of Histology, Vladivostok State Medical University, Russia

    I. V. Dyuizen, P. A. Motavkin & V. V. Shorin

Authors
  1. I. V. Dyuizen
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  2. P. A. Motavkin
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  3. V. V. Shorin
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Dyuizen, I.V., Motavkin, P.A. & Shorin, V.V. Dynamics of NADPH Diaphorase Activity in Raphe Neurons during Chronic Treatment with Opiates. Bulletin of Experimental Biology and Medicine 132, 918–920 (2001). https://doi.org/10.1023/A:1013151625135

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