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Effect of Mesna on Lethal Effect and Hematological Toxicity of Taxol and Vepeside in Mice

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Abstract

Mesna, an SH-containing uroprotector, attenuates the lethal effect and hematological toxicity of vepeside and taxol, but did not reduce specific activities of the studied cytostatics in mice with transplanted tumors. This selective antitoxic effect of mesna towards vepeside and taxol allows to intensify the anticancer chemotherapy with these highly effective but extremely toxic cytostatics and to improve the efficiency of anticancer therapy.

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REFERENCES

  1. T. A. Bogush, F. V. Donenko, and N. S. Saprykina, Vopr. Onkol., 75, 58-63 (1986).

    Google Scholar 

  2. T. A. Bogush, G. B. Smirnova, E. F. Chmutin, et al., Antibiot. Khimioter., 34, 30-35 (1994).

    Google Scholar 

  3. S. H. Advani, Aust. N. Z. J. Med., 28, No. 3, 410-413 (1998).

    PubMed  Google Scholar 

  4. H. Blomgren, M. Hallstrom, and H. Hillgren, Anticancer Res., 11, No. 2, 773-776 (1991).

    PubMed  Google Scholar 

  5. N. Brock, J. Pohl, J. Stekar, and W. Scheef, Eur. J. Cancer Oncol., 18, 1377-1387 (1982).

    Google Scholar 

  6. F. Di Silverio, M. Gallucci, G. P. Ricciuti, et al., Acta Urol. Ital., 2, 95-98 (1998).

    Google Scholar 

  7. M. P. Goren, L. B. Anthony, K. R. Hande, et al., J. Clin. Oncol., 16, No. 2, 616-621 (1998).

    PubMed  Google Scholar 

  8. M. Markman, A. Kennedy, K. Webster, et al., Semin. Oncol., 23, No. 3, Suppl. 6, 97-98 (1996).

    PubMed  Google Scholar 

  9. B. L. Pool, R. B. Bos, U. Niemeyer, et al., Toxicol. Lett., 41, No. 1, 49-56 (1988).

    PubMed  Google Scholar 

  10. D. Schmahl, M. Habs, and A. M. Tacchi, Urologe A., 23, No. 5, 291-296 (1984).

    PubMed  Google Scholar 

  11. L. L. Siu and M. J. Moore, Support Care Cancer, 6, No. 2, 144-154 (1998).

    PubMed  Google Scholar 

  12. V. T. Slott and B. F. Hales, Toxicol. Appl. Pharmacol., 82, No. 1, 80-86 (1986).

    PubMed  Google Scholar 

  13. A. Vermes, H. J. Guchelaar, and R. P. Koopmans, Cancer Treat. Rev., 23, 321-339 (1997).

    PubMed  Google Scholar 

  14. M. Wang, A. Nishikawa, and F. L. Chung, Chem. Res. Toxicol., 5, 528-531 (1992).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Medical Chemistry, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow

    T. A. Bogush, E. Yu. Koldaeva, G. B. Smirnova, E. A. Bogush, O. I. Konyaeva & S. A. Khrustalev

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  1. T. A. Bogush
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  2. E. Yu. Koldaeva
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  3. G. B. Smirnova
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  4. E. A. Bogush
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  5. O. I. Konyaeva
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  6. S. A. Khrustalev
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Bogush, T.A., Koldaeva, E.Y., Smirnova, G.B. et al. Effect of Mesna on Lethal Effect and Hematological Toxicity of Taxol and Vepeside in Mice. Bulletin of Experimental Biology and Medicine 132, 869–872 (2001). https://doi.org/10.1023/A:1013126919683

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  • DOI: https://doi.org/10.1023/A:1013126919683

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