Abstract
The depth of penetration of tritium atoms capable of isotope substitution, generated by thermal dissociation on a tungsten wire (thermal activation of tritium), into a solid target is considered. On the basis of calculations used in the theory of recoil atom stopping, with a lipid bilayer as example, the possibility of penetration of reactive atoms to a depth of up to 5 nm was demonstrated. This result is nicely consistent with the available experimental data. The possibility of “slipping” of atomic tritium, without loss of its reactivity, into cavities with a decreased electron density was suggested. This phenomenon should be taken into account when interpreting the results of studying biological macromolecules and their complexes by tritium planigraphy.
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Badun, G.A., Fedoseev, V.M. Permeability of Lipid Membranes for Atomic Tritium or Atom “Slipping” Effect and Its Role in Tritium Planigraphy. Radiochemistry 43, 301–305 (2001). https://doi.org/10.1023/A:1012872927896
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DOI: https://doi.org/10.1023/A:1012872927896