Use of Extraction Generator for Preparing a 99mTc Radiopharmaceutical

Abstract

Data are reported on the use of extraction generator for preparing high-purity ^99mTc from ⁹⁹Mo, and the quality of the solution of ^99mTc is studied. The radiolysis products of the extractant, methyl ethyl ketone (MEK), are examined; the major products are MEK dimers, and their content under operating conditions does not exceed 0.005%. A high degree of removal of both inorganic and organic impurities from the ^99mTc eluate obtained from the extraction generator (Radium Institute) is achieved. This ensures a high quality of radiopharmaceuticals prepared from this ^99mTc solution. The ^99mTc solution prepared with the extraction generator surpasses in quality the similar solution prepared with the sorption generator. When a centrifugal extractor is used for separating ⁹⁹Mo and ^99mTc, the concentration of MEK in the solution of ^99mTc does not exceed 0.04 mg ml^-1.