Abstract
A complete biological integration into the surrounding tissues (bone, gingiva) is a critical step for clinical success of a dental implant. In this work biomimetic coatings consisting either of collagen type I (for the gingiva region) and hydroxyapatite (HAP) or mineralized collagen (for the bone interface) have been developed as suitable surfaces regarding the interfaces. Additionally, using these biomimetic coatings as a matrix, adhesion peptides were bound to further increase the specificity of titanium implant surfaces. To enhance cell attachment in the gingiva region, a linear adhesion peptide developed from a laminin sequence (TWYKIAFQRNRK) was bound to collagen, whereas for the bone interface, a cyclic RGD peptide was bound to HAP and mineralized collagen using adequate anchor systems. The biological potential of these coatings deduced from cell attachment experiments with HaCaT human keratinocytes and MC3T3-E1 mouse osteoblasts showed the best results for collagen and laminin sequence coating for the gingiva region and mineralized collagen and RGD peptide coatings for regions with bone contact. Our concept opens promising approaches to improve the biological integration of dental implants.
© 2001 Kluwer Academic Publishers
Similar content being viewed by others
References
M. Brien, H. Schliephake, J. Becker and P. A. Reichart, Z. Zahnärtzl. Implantol. 14 (1998) 208.
D. Buser, R. K. Schenk, S. Steinemann, J. P. Fiorellini, C. H. Fox and H. Stich, J. Biomed. Mater. Res. 25 (1991) 889.
G. L. Delange and K. Donath, Biomaterials 9 (1988) 302.
L. W. Lindquist, B. Rockler and G. E. Carlsson, J. Prosthet. Dent. 59 (1988) 59.
M. Quirynen, H. C. Van Der Mei, C. M. Bollen, A. Schotte, M. Marechal and G. I. Doornbusch, J. Dent. Res. 72 (1993) 1304.
M. Quirynen, C. M. Bollen, W. Papaioannou, J. Van Eldere and D. Van Steonberghe, J. Oral Maxillofac. Impl. 11 (1996) 169.
C. D. Wu-Yuan, K. J. Eganhouse, J. C. Keller and K. S. Walters, J. Oral Implantol. 21 (1995) 207.
L. Vroman and A. L. Adams, J. Colloid Interface Sci. 111 (1986) 391.
D. M. Brunette, Int. J. Oral Maxillofac. Impl. 3 (1988) 231.
C. J. Kirkpatrick, M. Wagner, H. KÖhler, F. Bittinger, M. Otto and C. L. Klein, J. Mater. Sci. 8 (1997) 131.
K. Anselme, Biomaterials 21 (2000) 667.
J. C. Parks, H. M. Kim and J. S. Ko, J. Oral. Maxillofac. Impl. 13 (1998) 826.
J. W. Dean, K. C. Culbertson and A. M. Dangelo, J. Oral. Maxillofac. Impl. 10 (1995) 721.
K. C. Dee, T. T. Andersen and R. Bizios, J. Biomed. Mater. Res. 40 (1998) 371.
D. M. Ferris, G. D. Moodie, P. M. Diomond, C. W. D. Gioranni, M. G. Ehrlich and R. F. Valentini, Biomaterials 20 (1999) 2323.
B. F. Lowenberg, R. M. Pillar, J. E. Aubin, J. Sodek and A. H. Melcher, ibid. 9 (1988) 302.
D. A. Puleo and A. Nanci, ibid. 20 (1999) 2311.
S. Roessler, C. Wolf, D. Scharnweber and H. Worch, J. Adhes. Sci. Technol. 14 (2000) 453.
H. Worch in “Metals as Biomaterials”, edited by J. A. Helsen and H. J. Breme (John Wiley & Sons Ltd, 1998) p. 177.
P. Schaffner, J. Meyer, M. Dard, B. Nies, S. Verrier, H. Kessler and M. Kantlehner, J. Mater. Sci.: Mater. Med. 10 (1999) 837.
J. P. Mazzucotelli, C. Klein-Soyer, A. Beretz, C. Brisson, G. Archipoff and J. P. Cazenave, Int. J. Artif. Organs 14 (1991) 482.
S. Roessler, D. Scharnweber, R. Born, H. Worch, A. Sewing and M. Dard, in “Proceedings of the 6th World Biomaterials Congress” (Kamuela, Hawaii, May 2000, Transactions) p. 1040.
H. B. Wen, J. R. De Wijn, F. Z. Cui and K. De Groot, J. Biomed. Mater. Res. 41 (1998) 227.
M. Nomizu, W. H. Kim, K. Yamamura, A. Utani and Sang-Yo, J. Biol. Chem. 270 (1995) 20583.
M. Kantlehner, D. Finsinger, J. Meyer, P. Schaffner, A. Jonczyk, B. Diefenbacher, B. Nies and H. Kessler, Angew. Chem. 111 (1999) 587.
U. Geissler, U. Hempel, C. Wolf, D. Scharnweber, H. Worch and K. W. Wenzel, J. Biomed. Mater. Res. 51 (2000) 752.
S. Roessler, M. Stoelzel, R. Born, D. Scharnweber, H. Worch, A. Sewing and M. Dard, ibid. Submitted May, 2001.
A. Jonczyk, S. Goodman, B. Diefenbach, A. Sutter and H. Kessler, WO-A97/14716.
U. Landegren, J. Immunol. Meth. 67 (1984) 379.
S. Roessler, D. Scharnweber and H. Worch, J. Mater. Sci. Lett. 18 (1999) 577.
S. Roessler, C. Wolf, D. Scharnweber, H. Worch, A. Sewing and M. Dard, in “Proceedings of the 6th World Biomaterials Congress” (Kamuela, Hawaii, May 2000, Transactions) p. 1045.
A. Nanci, J. D. Wuest, L. Peru, P. Brunet, V. Sharma, S. Zalzal and M. D. McKee, J. Biomed. Mater. Res. 40 (1998) 342.
B. T. Houseman and M. Mrksich, Biomaterials 22 (2001) 943.
S. Ban and S. Maruno, J. Biomed. Mater. Res. 42 (1998) 387.
H. Ishizawa and M. Ogino, ibid. 31 (1996) 6279.
J. Redepenning, T. Schlessinger, S. Burnham, L. Lippiello and J. Miyano, ibid. 30 (1996) 287.
M. Shirkhanzadeh, J. Mater. Sci.: Mater. Med. 9 (1998) 67.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Roessler, S., Born, R., Scharnweber, D. et al. Biomimetic coatings functionalized with adhesion peptides for dental implants. Journal of Materials Science: Materials in Medicine 12, 871–877 (2001). https://doi.org/10.1023/A:1012807621414
Issue Date:
DOI: https://doi.org/10.1023/A:1012807621414