Abstract
A new method was developed for synthesis of 2-acetonyl-4-alkoxymethylbutanolides by treatment of 4-alkoxymethyl-2-(β-chloroallyl)butanolides with concentrated sulfuric acid and subsequent hydrolysis. 4-alkoxymethyl-2-(β-chloroallyl)butanolides are readily obtained by alkylation of accessible 4-alkoxymethyl-2-ethoxycarbonylbutanolides with 2,3-dichloropropene, followed by hydrolysis and decarboxylation of the resulting 4-alkoxymethyl-2-(β-chloroallyl)-2-ethoxycarbonylbutanolides.
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Arutyunyan, V.S., Kochikyan, T.V., Nalbandyan, Z.Y. et al. New Synthesis of 2-Acetonyl-4-alkoxymethylbutanolide. Russian Journal of Organic Chemistry 37, 109–111 (2001). https://doi.org/10.1023/A:1012389804196
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DOI: https://doi.org/10.1023/A:1012389804196