Abstract
Regularities of the peroxide fragmantation of human serum albumin, initiated by an iron(II) salt and hydrogen peroxide, are considered. A chain mechanism is proposed for this process, leading to generation of carbonyl fragments of the protein molecule.
Similar content being viewed by others
REFERENCES
Fridovich, I., Science, 1978, vol. 201, no. 4359, pp. 875-880.
Men'shikova, E.B., Zenkov, N.K., and Safina, A.F., Usp. Sovrem. Biol., 1997, vol. 117, no. 3, pp. 362-373.
Men'shikova, E.B. and Zenkov, N.K., Usp. Sovrem. Biol., 1997, vol. 117, no. 1, pp. 155-171.
Wolf, S.P., Garner, A., and Dean, R.T., Trends Biochem. Sci., 1986, vol. 11, no. 1, pp. 27-31.
Das, D., Bandyopadhyay, D., and Banerjee, R.K., Free Rad. Biol. Med., 1998, vol. 24, no. 3, pp. 460-469.
Langvist, H. and Dahlgren, C., Free Rad. Biol. Med., 1996, vol. 20, no. 6, pp. 785-792.
Srigiridhar, K. and Modhavan Nair, K., Free Rad. Biol. Med., 1998, vol. 25, no. 6, pp. 660-665.
Kotch, L.E., Chen, S.Y., and Sulik, K.K., Teratology, 1995, vol. 52, no. 2, pp. 128-136.
Brown, K.E. and Knudsen, C.A., Free Rad. Biol. Med., 1998, vol. 24, no. 2, pp. 239-244.
Natural Antioxidants in Human Health and Disease, Frei, B., Ed., New York: Academic, 1994.
Ischiropoulos, H. and Al-Meholi, A.B., FEBS Lett., 1995, vol. 364, no. 3, pp. 279-282.
Gatti, R.M., Radi, R., and Augusto, O., FEBS Lett., 1994, vol. 348, no. 3, pp. 287-290.
Ereal, N., Treeratphan, P., Hammond, T.C., Matthews, R.H., Grannemann, N.H., and Spits, D.K., Free Rad. Biol. Med., 1996, vol. 21, no. 2, pp. 157-161.
Ketterer, B., Loles, B., and Meyer, D.J., Environ. Health. Perspect., 1983, vol. 49, no. 1, pp. 59-69.
Hsu, J.M., J. Nutrit., 1981, vol. 111, no. 1, pp. 26-33.
Reznik, A.Z. and Packer, L., Methods Enzymol. C, 1994, vol. 233, pp. 357-363.
Lee, Y. and Schacher, E., Arch. Biochem. Biophys., 1995, vol. 321, no. 1, pp. 175-181.
Reinkeckel, T., Medelev, B., Prause J. Augustin, W., Schulz, H.U., Lippert, H., and Halangk, W., Free Rad. Biol. Med., 1998, vol. 24, no. 3, pp. 393-400.
Levine, R.L., Williams, J.A., Stadtman, E.R., and Schacher, E., Methods Enzymol. C, 1994, vol. 233, pp. 346-357.
Zenkov, N.K. and Men'shikova, E.B., Usp. Sovrem. Biol., 1996, vol. 116, no. 6, pp. 729-748.
Reszka, K.J., Matuszak, L., and Chignell, C.F., Free Rad. Biol. Med., 1998, vol. 25, no. 2, pp. 208-216.
Halliwell, B. and Gutteridge, J.M.C., Arch. Biochem.
Winston, G.W., Regoli, F., Dugas, A.J., Fong, J.H., and Blanchard, K.A., Free Rad. Biol. Med., 1998, vol. 24, no. 3, pp. 480-493.
Halliwell, B. and Gutteridge, J.M.C., Methods Enzymol., 1990, vol. 186, no. 1, pp. 1-85.
Stroev, E.A., Biologicheskaya khimiya (Biological Chemistry), Moscow: Vysshaya Shkola, 1986.
Tyukavina, N.A. and Baukov, Yu.I., Bioorganicheskaya khimiya (Bioorganic Chemistry), Moscow: Meditsina, 1985.
Shulz, G. and Schirmer, R., Principles of Protein Structure, New York: Springer, 1979.
Shikama, K., Chem. Rev., 1998, vol. 98, no. 4, pp. 1357-1373.
Stubbe, J. and Donk, W.A. van der, Chem. Rev., 1998, vol. 98, no. 2, pp. 705-762.
Dubinina, E.E. and Shugalei, I.V., Usp. Sovrem. Biol., 1993, vol. 113, no. 1, pp. 71-81.
Igumenov, V.L., Sharonov, B.P., and Pasechnikov, V.A., Biokhimiya, 1988, vol. 53, no. 6, pp. 925-930.
Pal'm, V.A., Osnovy kolichestvennoi teorii organicheskikh reaktsii (Principles of Quantitative Theory of Organic Reactions), Leningrad: Khimiya, 1977.
Emanuel', N.M. and Evseenko, L.S., Kolichestvennye osnovy klinicheskoi onkologii (Quantitative Principles of Clinical Oncology), Moscow: Meditsina, 1970.
Emanuel', N.M., Denisov, E.T., and Maizus, Z.K., Tsepnye reaktsii okisleniya uglevodorodov v zhidkoi faze (Chain Reactions of Liquid-Phase Oxidation of Hydrocarbons), Moscow: Nauka, 1965.
Emanuel', N.M., Zaikov, G.E., and Maizus, Z.K., Rol' sredy v radikal'no-tsepnykh reaktsiyakh okisleniya organicheskikh soedinenii (Role of Medium in Radical-Chain Oxidation Reactions of Organic Reactions), Moscow: Nauka, 1973.
Emanuel', N.M. and Knorre, D.G., Kurs khimicheskoi kinetiki (Handbook on Chemical Kinetics), Moscow: Vysshaya Shkola, 1974.
Emanuel', N.M., Zaikov, G.E., and Kritsman, V.A., Tsepnye reaktsii. Istoricheskii aspekt (Chain Reactions. A Historical Aspect), Moscow: Nauka, 1989.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shugalei, I.V., Lukogorskaya, S.A., Tselinskii, I.V. et al. Mechanisms of Initiated Protein Peroxidation Accompanied by Generation of Carbonyl Fragments. Russian Journal of General Chemistry 71, 633–638 (2001). https://doi.org/10.1023/A:1012355823469
Issue Date:
DOI: https://doi.org/10.1023/A:1012355823469