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Medulloblastoma Displays Distinct Regional Matrix Metalloprotease Expression

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Abstract

Matrix metalloproteases (MMPs) play an important role in tissue remodeling and neoangiogenesis during tumor progression. Little is known about the presence and regional distribution of MMPs in medulloblastomas. Based on immunohistochemical, immunocytochemical and zymographical analysis the present study illustrates the differential pattern of MMP expression for the medulloblastoma compared to that of glioma and ependymoma. In 10 examined medulloblastoma tumors gelatinase-A was strongly expressed by clusters of tumor cells. Gelatinase-B was, similar to glioma and ependymoma, predominantly found around endothelial cells. The DAB signal for macrophage metalloelastase was seen around macrophages and matrilysin was expressed by single tumor cells. Stromelysin-1 protein was detected in medulloblastoma but not in glioma or ependymoma. From the presented data it follows that each tumor entity might display its own characteristic MMP expression pattern.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Wuerzburg, Wuerzburg, Germany

    Giles H. Vince, Christian Herbold, Stefanie Franz, Klaus Roosen & Jörg-Christian Tonn

  2. Institute of Pathology, Department of Neuropathology, University of Wuerzburg, Wuerzburg, Germany

    Rüdiger Klein & Joachim Kühl

  3. Department of Neuropathology, University of Bonn, Bonn, Germany

    Torsten Pietsch

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  1. Giles H. Vince
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  2. Christian Herbold
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  3. Rüdiger Klein
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  8. Jörg-Christian Tonn
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Vince, G.H., Herbold, C., Klein, R. et al. Medulloblastoma Displays Distinct Regional Matrix Metalloprotease Expression. J Neurooncol 53, 99–106 (2001). https://doi.org/10.1023/A:1012241031138

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