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Endoplasmic reticulum in the heart, a forgotten organelle?

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Abstract

Our hypothesis is that sarcoplasmic and endoplasmic reticulum Ca2+ stores may be functionally distinct compartments in cardiomyocytes. Sarcoplasmic reticulum Ca2+ store is responsible for control of excitation-contraction coupling whereas endoplasmic reticulum compartment may provide Ca2+ for housekeeping and transcriptional functions.

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Authors and Affiliations

  1. Canadian Institutes of Health Research Group in Molecular Biology of Membrane Proteins and the Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada

    Nasrin Mesaeli, Kimitoshi Nakamura & Marek Michalak

  2. Department of Pediatrics, Kumamoto University, School of Medicine, Kumamoto, Japan

    Kimitoshi Nakamura

  3. Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario, M5S lA8, Canada

    Michal Opas

Authors
  1. Nasrin Mesaeli
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  2. Kimitoshi Nakamura
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  3. Michal Opas
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  4. Marek Michalak
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Correspondence to Marek Michalak.

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Mesaeli, N., Nakamura, K., Opas, M. et al. Endoplasmic reticulum in the heart, a forgotten organelle?. Mol Cell Biochem 225, 1–6 (2001). https://doi.org/10.1023/A:1012209923231

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