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Characteristics of Intracellular Ca2+ Handling Proteins in Heart Function in Health and Disease

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Heart Rate and Rhythm

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Abstract

In view of its ability to release and accumulate Ca2+, the sarcoplasmic reticulum (SR) plays a major role in cardiomyocyte excitation–contraction coupling. Since Ca2+ is important in the functions of both mitochondria and nucleus, it appears that these organelles are involved in excitation–metabolism coupling and excitation–transcription coupling. This brief article discusses some of the characteristics of the SR, mitochondria, and nucleus with respect to their Ca2+ transport systems in cardiomyocytes and the role of Ca2+ in different coupling processes. In addition, the influence of fluctuations in the cytoplasmic Ca2+ concentration on cardiomyocyte contractile activity, metabolism, and gene expression in heart disease is presented. The potential of the SR and the mitochondria and nucleus as therapeutic targets for the treatment of heart disease is also highlighted.

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Acknowledgements

The infrastructural support for the work presented in this article was provided by the St. Boniface Hospital Research Foundation. Dr. Nusier is a Visiting Professor from Jordan University of Science and Technology, School of Medicine, Department of Physiology and Biochemistry, Jordan.

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Authors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre & Department of Physiology and Pathophysiology, College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

    Naranjan S. Dhalla & Mohamad Nusier

  2. Department of Kinesiology and Nutritional Sciences, California State University, Los Angeles, CA, USA

    Anureet K. Shah

  3. Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, MB, Canada

    Paramjit S. Tappia

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  1. Naranjan S. Dhalla
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Correspondence to Naranjan S. Dhalla .

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  1. Cardiac Electrophysiology Division, Ion Channel Study Center, Life Science Academy, Lucknow, India

    Onkar N. Tripathi

  2. Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada

    T. Alexander Quinn

  3. Institute for Experimental Cardiovascular Medicine, University Heart Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Ursula Ravens

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Dhalla, N.S., Nusier, M., Shah, A.K., Tappia, P.S. (2023). Characteristics of Intracellular Ca2+ Handling Proteins in Heart Function in Health and Disease. In: Tripathi, O.N., Quinn, T.A., Ravens, U. (eds) Heart Rate and Rhythm. Springer, Cham. https://doi.org/10.1007/978-3-031-33588-4_21

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