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Comprehensive Approach to Functional State Evaluation in Humans: Report I. Methodology of Diagnosis of the Functional State

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Abstract

By means of a complex of cost-effective, rapid, and, whenever possible, computerized screening procedures, a systematic two-week study period of the functional states of subjects in a small group of healthy adults was performed. The daily variations of 125 parameters and periodic changes in 51 parameters of somatic and mental health were investigated at increasing doses of an adaptive drug. In the initial state of the subjects, various deviations of the somatic parameters from the normal level were found, presumably of a nutritional origin. The adaptive drug was found to normalize the changed parameters of somatic health within a week due to a strain in the regulatory systems and a decline in the functional reserves of adaptation. At the end of the examination, excessive doses of the adaptive drug returned the majority of the somatic parameters to the initial levels. At the same time, the work capacity of the subjects decreased and the strain on the autonomic nervous system and the level of stress increased. Discomfort and fatigue developed, which restricted the abilities of the examined subjects to choose behavioral tactics.

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Authors and Affiliations

  1. Kemerovo State University, Russia

    E. M. Kazin, E. A. Anisova, A. R. Galeev, I. L. Golenda, E. S. Gol'dshmidt, K. V. Grishina, R. G. Drapezo, L. N. Igisheva, V. V. Minin, O. V. Ovchinnikova & S. V. Shabasheva

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  1. E. M. Kazin
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  2. E. A. Anisova
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  3. A. R. Galeev
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  4. I. L. Golenda
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  5. E. S. Gol'dshmidt
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  8. L. N. Igisheva
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Kazin, E.M., Anisova, E.A., Galeev, A.R. et al. Comprehensive Approach to Functional State Evaluation in Humans: Report I. Methodology of Diagnosis of the Functional State. Human Physiology 27, 228–238 (2001). https://doi.org/10.1023/A:1011091719770

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