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Features of Auditory P300 in Relatives of Schizophrenic Patients

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Abstract

The subjects were parents, siblings, and children of schizophrenic patients. Auditory evoked potentials (EPs) (P300) were recorded in the standard oddball paradigm with a probability of the target stimuli presentation of 0.2 and sound (tone) intensity of 60 dB. A comparison of these data with the results of the examination of reference groups (normal subjects free of a family history of mental pathology) showed significantly longer latent periods of N1, N2, and P3 in EPs to target stimuli in siblings and children of schizophrenic patients, as well as significantly decreased amplitudes of N1 and P2 in EPs to nontarget (standard) stimuli and longer latent periods of N2 in EPs to target stimuli in the parents of schizophrenic patients.

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REFERENCES

  1. Gnezditskii, V.V., Vyzvannye potentsialy mozga v klinicheskoi praktike (Evoked Brain Potentials in Clinical Practice), Taganrog: Taganrogsk. Gos. Radiotekhn. Univ., 1997.

    Google Scholar 

  2. McCarley, R., O'Donnell, B., Niznikiewicz, M., et al., Update on Electrophysiology in Schizophrenia, Int. Rev. Psychiatry, 1997, vol. 9, p. 373.

    Google Scholar 

  3. Hegerl, U., Event-Related Potentials in Psychiatry, in Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, Niedermeyer, E. and Lopez da Silva, F., Eds., Williams & Wilkins, Waverly, 1999, 4th ed., p. 621.

    Google Scholar 

  4. Naatanen, R. and Picton, T., The N1 Wave of the Human Electric and Magnetic Response to Sound: A Review and an Analysis of the Component Structure, Psychophysiology, 1987, vol. 24, no. 4, p. 375.

    Google Scholar 

  5. Ivanitskii, A.M., Strelets, V.B., and Korsakov, I.A., Informatsionnye protsessy mozga i psikhicheskaya deyatel'nost' (Cerebral Information Processes and Mental Activity), Moscow: Nauka, 1984.

    Google Scholar 

  6. Kanunikov, I.E. and Vetosheva, V.I., Modern Concepts of the Psychophysiological Significance of P300, Fiziol. Chel., 1988, vol. 14, no. 2, p. 314.

    Google Scholar 

  7. Polich, J., P300 in Clinical Applications: Meaning, Method, and Measurement, Am. J. EEG Technol., 1991, vol. 31, p. 201.

    Google Scholar 

  8. Kostandov, E.A., Zakharova, N.N., Reshchikova, T.N., and Chak”rov, V.E., Impairment of the Information Selection Mechanism in Schizophrenic Patients, Zh. Nevropatol. Psikhiat., 1993, vol. 93, no. 4, p. 55.

    Google Scholar 

  9. Lebedeva, I.S., Orlova, V.A., Kaleda, V.G., and Tsutsul'kovskaya, M.Ya., P300 of Auditory Evoked Potentials in Schizophrenia, Zh. Nevropatol. Psikhiat., 2000, vol. 100, no. 11, p. 47.

    Google Scholar 

  10. Kutcher, S., Blackwood, D., St. Clair, D., et al., Auditory P300 in Borderline Personality Disorder and Schizophrenia, Arch. Gen. Psychiatry, 1987, vol. 44, no. 7, p. 645.

    Google Scholar 

  11. Ogura, C., Nageishi, Y., Matsubayashi, M., et al., Abnormalities in Event-Related Potentials, N100, P200, P300 and Slow Wave in Schizophrenia, Jpn. J. Psychiatry Neurol., 1991, vol. 45, no. 1, p. 57.

    Google Scholar 

  12. Friedman, D. and Squires-Wheeler, E., Event-Related Potentials (ERPs) as Indicators of Risk for Schizophrenia, Schizophrenia Bull., 1994, vol. 20, no. 1, p. 63.

    Google Scholar 

  13. Kidogami, Y., Yoneda, H., Asaba, H., and Sakai, T., P300 in First Degree Relatives of Schizophrenic Patients, Schizophrenia Res., 1991, vol. 6, no. 1, p. 9.

    Google Scholar 

  14. Kimble, M., Lyons, N., O'Donnell, B., et al., The Effect of Family Status and Schizotypy on Electrophysiologic Measures of Attention and Semantic Processing, Biol. Psychiatry, 2000, vol. 47, no. 5, p. 402.

    Google Scholar 

  15. Turetsky, B., Cannon, T., and Gur, R., P300 Subcomponent Abnormalities in Schizophrenia: III. Deficits in Unaffected Siblings of Schizophrenic Probands, Biol. Psychiatry, 2000, vol. 47 no. 5, p. 380.

    Google Scholar 

  16. Schreiber, H., Stolz-Born, G., Rothmeier, J., et al., Endogenous Event-Related Brain Potentials and Psychometric Performance in Children at High Risk for Schizophrenia, Biol. Psychiatry, 1991, vol. 30, no. 2, p. 177.

    Google Scholar 

  17. Karoumi, B., Laurent, A., Rosenfeld, F., et al., Alteration of Event-Related Potentials in Siblings Discordant for Schizophrenia, Schizophrenia Res., 2000, vol. 41, no. 2, p. 325.

    Google Scholar 

  18. Blackwood, D., St. Clair, D., Muir, W., and Duffy, J., Auditory P300 and Eye Tracking Dysfunction in Schizo-phrenic Pedigrees, Arch. Gen. Psychiatry, 1991, vol. 48, no. 10, p. 899.

    Google Scholar 

  19. Frangou, S., Sharma, T., Alarcon, G., et al., The Maudsley Family Study: II. Endogenous Event-Related Potentials in Familial Schizophrenia, Schizophrenia Res., 1997, vol. 23, no. 1, p. 45.

    Google Scholar 

  20. Roxborough, T., Muir, W., Blackwood, D., et al., Neuropsychological and P300 Abnormalities in Schizophrenic Patients and Their Relatives, Psychol. Med., 1993, vol. 23, no. 2, p. 305.

    Google Scholar 

  21. Polich, J., P300 in Clinical Application, in Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, Niedermeyer, E. and Lopez da Silva, F., Eds., Williams & Wilkins, Waverly, 1999, 4th ed., p. 1073.

    Google Scholar 

  22. Waldo, M., Adler, L., and Freedman, R., Defects in Auditory Sensory Gating and Their Apparent Compensation in Relatives of Schizophrenic Patients, Schizophrenia Res., 1988, vol. 1, p. 19.

    Google Scholar 

  23. Michalewski, H., Prasher, D., and Starr, A., Latency Variability and Temporal Interrelationships of the Auditory Event-Related Potentials (N1, P2, N2, and P3) in Normal Subjects, Electroenceph. Clin. Neurophysiol., 1986, vol. 65, no. 1, p. 59.

    Google Scholar 

  24. Hirayasu, Y., Asato, N., Ohta, H., et al., Abnormalities of Auditory Event-Related Potentials in Schizophrenia Prior to Treatment, Biol. Psychiatry, 1998, vol. 43, p. 244.

    Google Scholar 

  25. Muir, W., St. Clair, D., and Blackwood, D., Long-Latency Auditory Event-Related Potentials in Schizophrenia and in Bipolar and Unipolar Affective Disorder, Psychol. Med., 1991, vol. 21, no. 4, p. 867.

    Google Scholar 

  26. O'Donnell, B., Hokama, H., McCarley, R., et al., Auditory ERPs to Non-Target Stimuli in Schizophrenia: Relationship to Probability, Task-Demands, and Target ERPs, Int. J. Psychophysiol., 1994, vol. 17, p. 219.

    Google Scholar 

  27. Lebedeva, I.S., Orlova, V.A., and Savina, T.D., P300 in the Families of Schizophrenic Patients, Am. J. Med. Genetics, 1998, vol. 81, no. 6, p. 496.

    Google Scholar 

  28. Naatanen, R. and Picton, T., N2 and Automatic vs Controlled Processes, in Cerebral Psychophysiology: Studies in Event-related Potentials (EEG Suppl. 38), McCallum, W., Zappoli, R., and Denoth, F., Eds., New York: Elsevier, 1986, p. 169.

    Google Scholar 

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Authors and Affiliations

  1. Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia

    I. S. Lebedeva & V. A. Orlova

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  1. I. S. Lebedeva
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  2. V. A. Orlova
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Lebedeva, I.S., Orlova, V.A. Features of Auditory P300 in Relatives of Schizophrenic Patients. Human Physiology 27, 289–293 (2001). https://doi.org/10.1023/A:1010961603716

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