Skip to main content
SpringerLink
Log in

Dynamics of Blood Serum Levels of Follicle-Stimulating Hormone, Luteinizing Hormone, Prolactin, Estradiol, and Progesterone in Right- and Left-Handed Women

  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

The dynamics of follicle-stimulating hormone (FSH) luteinizing hormone (LH), prolactin (PRL), estradiol (E2), and progesterone were studied in left- and right-handed women having a stable 28-day menstrual cycle. The hormones were determined by enzyme immunoassays on days 3, 8, 10, 13, 16, 22, 26, and 28 of the menstrual cycle. The data showed that bllod serum levels of FSH, LH, PRL, and E2are higher in left-handed in comparison to right-handed women (p< 0.001). On days 10 through 28 of the cycle, the level of progesterone is also higher in left-handed women (p< 0.001). The dynamic of these hormones in left-handed and right-handed women appeared to remain within the normal limits. These findings indicate that the handedness correlates with the dynamucs of serum levels of these hormones. Higher serum levels of hormones in left-handed women suggests that they have higher levels of the functional activity of the hypophysis–ovarian axis and prolactin axis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Bragina, N.N. and Dobrokhotova, T.A., Funktsional'nye asimmetrii cheloveka (Human Functional Asimmetry), Moscow: Meditsina, 1988, p. 11.

    Google Scholar 

  2. Vartanyan, G.A. and KlementÌev, B.I., Problem of the brain chemical asymmetry, Fiziol.Chel., 1988, vol. 14, no. 2, p. 297.

    Google Scholar 

  3. Bianki, V.L., Mekhanizmy parnogo mozga (Mechanisms of the Dual Brain) Leningrad: Nauka, 1989, p. 5.

    Google Scholar 

  4. Kolyshkin, V.A., Functional Asymmetry of Brain and its Role in the Genesis of Arterial Hypertension, Fiziol. Chel., 1993, vol. 15, no. 5, p. 23.

    Google Scholar 

  5. Chernositova, A.V., Orlov, V.I., and KuzÌmin, A.V., Interrelation of the Functional Brain Hemispheric Asymmetry and Morphological and Functional Asymmetries of Female Reproductive System from the Viewpoint of Comparative Evolution, Zh. Vyssh. Nervn. Deyatel'nosti, 1994, vol. 44, no. 2, p. 334.

    Google Scholar 

  6. Corballis, M.C., Lee, K., McManus, I.C., and Crow, T.J., Location of the Handedness Gene on the X and Y Chromosomes, Am. J. Med. Genetics, 1996, vol. 67, p. 50.

    Google Scholar 

  7. Rebai, M., Lannon, J., Bernard, C., et al., Hemispheric Asymmetries of Visual Evoked Potentials in Relation to Spatial Frequency, Handedness, and Familial Left-Handedness, Int. J. Psychophysiol., 1997, vol. 25, p. 85.

    Google Scholar 

  8. Ellias, L.J., Bryden, A., and Bulman-Fleming, M.B., Footedness Is a Better Predictor than Is Handedness of Emotional Lateralization, Neuropsychologia, 1999 8, vol. 36, p. 37.

    Google Scholar 

  9. Geschwind, N. and Galaburda, A.M., Cerebral Lateralization. Biological Mechanisms, Association, and Pathology: I. A Hypothesis and a Program for Research, Arch. Neurol., 1985, vol. 42, p. 428.

    Google Scholar 

  10. Leidy, L.E., Early Age of Menopause among Left-Handed Women, Obstetrics Gynecol., 1990, vol. 76, p. 1111.

    Google Scholar 

  11. Nikolova, P., Negrev, N., Stoyanov, Z., and Nikolova, R., Functional Brain Asymmetry, Handedness, and Age Characteristics of Climacterium in Women, Int. J. Neuroscience, 1996, vol. 86, p. 143.

    Google Scholar 

  12. Tan, U., Serum Testosterone Levels in Male and Female Subjects with Standard and Anomalous Dominance, Int. J. Neuroscience, 1991, vol. 58, p. 211.

    Google Scholar 

  13. Tan, U., Testosterone and Estradiol in Right-Handed Men but Only Estradiol in Right-Handed Women Is Inversely Correlated with the Degree of Right-Hand Preference, Int. J. Neuroscience, 1992, vol. 66, p. 25.

    Google Scholar 

  14. Babichev, V.N., Neiro-gormonal'naya regulyatsiya ovarial'nogo tsikla (Neurohormonal Regulation of Ovarian Cycle), Moscow: Meditsina, 1984, p. 36.

    Google Scholar 

  15. Krupko-BolÌshova, Zh.A., Ginekologicheskaya endokrinologiya devochek and devushek (Gynecologic Endocrinology of Little and Young Girls), Kiev: Zdorov'ya, 1986, p. 41.

    Google Scholar 

  16. Nakajima, S.T., Molloy, M.H., Oi, R.H., et al., Clinical Evaluations of Luteal Function, Obstetrics Gynecol., 1994, vol. 84, p. 219.

    Google Scholar 

  17. Cagnacci, A., Volpe, A., Paoletti, A.M., and Melis, G.B., Regulation of the 24-Hour Rhythm of Body Temperature in Menstrual Cycles with Spontaneous and Gonadotropin-Induced Ovulation, Fertility Sterility, 1997, vol. 68, p. 421.

    Google Scholar 

  18. Oldfield, R.C., The Assessment and Analysis of Handedness: The Edinburgh Inventory, Neuropsychologia, 1971, vol. 9, p. 97.

    Google Scholar 

  19. Annett, M., The Dustribution of Manual Asymmetry, Br. J. Psychol., 1972, vol. 63, p. 343.

    Google Scholar 

  20. Raczkowski, D., Kalat, J.W., and Nebes, R., Reliability and Validity of Some Handedness Questionnaire Items, Neuropsychologia, 1974, vol. 12, p. 43.

    Google Scholar 

  21. Salmaso, D. and Longoni, A.M., Problems in the Assessment of Hand Preference, Cortex, 1985, vol. 21, p. 533.

    Google Scholar 

  22. Leutin, V.P. and Nikolaeva, E.I., Psikhofiziologicheskie mekhanizmy adaptatsii i funktsionalÌnaya asimmetriya mozga (Psychophysiological Adaptation Mechanisms and Brain Functional Asymmetry), Novosibirsk: Nauka, 1988, p. 104.

    Google Scholar 

  23. Nestor, P.G. and Safer, M.A., A Multi-Method Investigation of Individual Differences in Hemisphericity, Cortex, 1990, vol. 26, p. 409.

    Google Scholar 

  24. Rachev, E. and Vasilev, P., Klimakterium u zhenata (Climax in Women), Sofia, Meditsina i Fizkultura, 1990, p. 112.

  25. Greenspan, F.S., Basic and Clinical Endocrinology, London: Prentice-Hall International (UK) Limited, 1991, p. 112.

    Google Scholar 

  26. Lazarov, S., Laboratorni biokonstanti pri choveka (Laboratory Biological Constants in Man), Sofia, Meditsina i Fizkultura, 1994, p. 44.

    Google Scholar 

  27. Rossmanith, W.G., Zirkadiane und ultradiane Rhythmen in der Gonadotropinsekretion: Regulation durch ovarielle Steroide, Geburtshilfe Frauenheilkunde, 1991, Bd. 51, S. 585.

    Google Scholar 

  28. Miyauchi, F., Nanjo, K., and Otsuka, K., Effevts of Night Shift on Plasma Concentrations of Melatonin, LH, FSH, and Prolactin and Menstrual Irregularity, Jap. J. Industrial Health, 1992, vol. 34, p. 545.

    Google Scholar 

  29. Mortola, J.E., Laughlin, G.A., and Yen, S.S., A Circadian Rhythm of Serum Follicle-Stimulating Hormone in Women, J. Clin. Endocrinol. Metab., 1992, vol. 75, p. 861.

    Google Scholar 

  30. Rossmanith, W.G., Boscher, S., Kern, W., and Fehm, H.L., Impact of Sleep on the Circadian Excursions in the Pituitary Gonadotropin Responsiveness of Early Follicular Phase Women, J. Clin. Endocrinol. Metab., 1993, vol. 76, p. 330.

    Google Scholar 

  31. McNatty, K.P., Sawers, R., McNeilly, A.S., A Possible Role for Prolactin in Control of Steroid Secretion by the Human Graafian Follicle, Nature, 1994, vol. 250, p. 653.

    Google Scholar 

  32. Filicori, M., Tabarelli, C., Casadio, P., et al., Interaction between Menstrual Cyclicity and Gonadotropin Pulsatility, Horm. Res., 1998, vol. 49, p. 169.

    Google Scholar 

  33. Horsky, J. and Presl, J., Ovarian Function and Its Disorders, The Hague: Martinus Nijhoff Publishers, 1981, p. 11.

    Google Scholar 

  34. Tepperman, J. and Tepperman H.M., Metabolic and Endocrine Physiology,Chicago, London, 1987 . Translated under the title Fiziologiya obmena veshchestv i endokrinnoi sistemy, Moscow: Mir, 1989. p. 245.

  35. Caraty, A., Evans, N.P., Fabre-Nys, C.L., and Karasch, E.J., The Preovulatory Gonadotropin-Releasing Hormone Surge: a Neuroendocrine Signal for Ovulation, J. Reproduction Fertility ,1995, vol 49, p. 245.

    Google Scholar 

  36. Van Goozen, S.H., Wiegant, V.M., Endert, E., et al.,Psychoendocrinological Assessment of the Menstrual Cycle: the Relationship between Hormones, Sexuality, and Mood, Arch. Sexual Behav., 1997, vol. 26, p. 359.

    Google Scholar 

  37. Kim, Y.K., Wasser, S.K., Fujimoto, V.Y., et al.,Utility of Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), Oestradiol, and FSH:LH Ratio in Predicting Reproductive Age in Normal Women, Hum. Reproduction ,1997, vol. 12, p. 1152.

    Google Scholar 

  38. Leach, R.E., Moghissi, K.S., Randolph, J.E., et al.,Intensive Hormone Monitoring in Women with Unexplained Infertility: Evidence for Subtle Abnormalities Suggestive of Diminished Ovarian Reserve, Fertility Sterility ,1997, vol. 68, p. 413.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Varna Medical University, Republic of Bulgaria

    N. N. Negrev, P. P. Nikolova & R. I. Nikolova

Authors
  1. N. N. Negrev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. P. Nikolova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. I. Nikolova
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Negrev, N.N., Nikolova, P.P. & Nikolova, R.I. Dynamics of Blood Serum Levels of Follicle-Stimulating Hormone, Luteinizing Hormone, Prolactin, Estradiol, and Progesterone in Right- and Left-Handed Women. Human Physiology 27, 468–471 (2001). https://doi.org/10.1023/A:1010923121891

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1010923121891

Keywords

Search

Navigation