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The Systemic Effects of Ovarian Aging

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Ovarian Aging

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Abstract

Ovarian aging characterizes menopausal syndrome, which is a dynamic decline in ovarian function and hormone secretion, causing physical and mental symptoms. The menopausal syndrome presentation depends on race, climate, genetics, nutrition, weight, height, birth, and other factors. The average age at which a woman enters perimenopause is 40 years, lasting an average of 4 years but up to 10 years. The root cause of the menopausal syndrome is a decline in ovarian endocrine function, especially estrogen concentration. Primordial follicle depletion accelerates and periodic follicle recruitment and the estrogen concentration decrease starting around the age of 37.5 years. Further, the hypothalamic-pituitary-ovarian (HPO) axis feedback regulation induces an increase in follicle-stimulating hormone (FSH) and a decrease in anti-Müllerian hormone (AMH) and the antral follicle count (AFC).

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  1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Shuhong Yang, Suzhen Yuan, Sheng Wang, Jingyi Wen, Mingfu Wu & Lu Shen

  2. Department of Psychiatry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Xiaofan Zhang

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Yang, S. et al. (2023). The Systemic Effects of Ovarian Aging. In: Wang, S. (eds) Ovarian Aging. Springer, Singapore. https://doi.org/10.1007/978-981-19-8848-6_3

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