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Melting Curves of Terfenadine Crystallized from Different Solvents

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Abstract

Several samples of terfenadine prepared by crystallization from different solvents under different experimental conditions were studied. The DSC curves obtained at a heating rate of 1°C min−1 afforded the temperature of melting and the mole fractions of the components of each sample. Certain of the samples were composed of two solid phases mixed in molar ratios varying between nearly one and a single structural form. Three polymorphic forms were identified.

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Authors and Affiliations

  1. Faculdade de Farmácia, Universidade de Coimbra, 3000, Coimbra

    J. Canotilho, F. S. Costa & A. T. Sousa

  2. Departamento de Química, Faculdade de Ciencias e Tecnologia, Universidade de Coimbra, 3000, Coimbra, Portugal

    J. S. Redinha & M. L. P. Leitão

Authors
  1. J. Canotilho
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  2. F. S. Costa
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  3. A. T. Sousa
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  4. J. S. Redinha
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  5. M. L. P. Leitão
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Canotilho, J., Costa, F.S., Sousa, A.T. et al. Melting Curves of Terfenadine Crystallized from Different Solvents. Journal of Thermal Analysis and Calorimetry 54, 139–149 (1998). https://doi.org/10.1023/A:1010173020159

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  • DOI: https://doi.org/10.1023/A:1010173020159

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