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The Relationship Between Rate of Administration of an Intubating Dose of Rocuronium and Time to 50% and 90% Block at the Adductor Pollicis Muscle

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Abstract

Objective.To determine the relationship between the rate ofrocuronium injection and the onset time of neuromuscular block. Methods.After intravenous induction, 60 female patients (ASA I–II) wereassigned randomly into 3 groups for rocuronium administration within1–15, 15–30 or 30–60 seconds. Acceleromyography of the thumbwas performed using train-of-four (TOF) stimulation. Times to 50% and 90%twitch depression of the first twitch of the TOF stimulation (T1) wererecorded. Results.Injection time significantly influences time to 50%relaxation, but not time to 90% relaxation. Body mass index is negativelycorrelated with time to 50% and 90% relaxation. Conclusions.Weconclude that rate of injection influences only the initial phase ofdevelopment of the block and that slower injection times do not significantlyaffect time to 90% relaxation at the adductor pollicis muscle.

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Authors and Affiliations

  1. Research Group for Experimental Anesthesiology and Clinical Pharmacology, University of Groningen, Groningen, The Netherlands

    A. De Haes & D. J. Eleveld

  2. Research Group for Experimental Anesthesiology and Clinical Pharmacology, University of Groningen, Groningen, The Netherlands

    J. M. K. H. Wierda

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  1. A. De Haes
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  2. D. J. Eleveld
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  3. J. M. K. H. Wierda
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De Haes, A., Eleveld, D.J. & Wierda, J.M.K.H. The Relationship Between Rate of Administration of an Intubating Dose of Rocuronium and Time to 50% and 90% Block at the Adductor Pollicis Muscle. J Clin Monit Comput 16, 219–222 (2000). https://doi.org/10.1023/A:1009964305762

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  • DOI: https://doi.org/10.1023/A:1009964305762

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