Abstract
The protein C anticoagulant pathway provides an “on demand” anticoagulant response whenever thrombin is generated. Activated protein C appears to possess both anticoagulant and anti-inflammatory properties. The function of the pathway is impaired in sepsis, including the consumption of protein C and protein S, two plasma components of the pathway. Supplementation with protein C or activated protein C has been shown to inhibit the disseminated intravascular coagulation (DIC) response in experimental animals and patients. Preliminary clinical results suggest that supplementation with components of the pathway may be useful in some patients with sepsis or septic shock.
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Esmon, C.T. New Potential Therapeutic Modalities: aPC. Sepsis 3, 161–171 (1999). https://doi.org/10.1023/A:1009859702238
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DOI: https://doi.org/10.1023/A:1009859702238