Abstract
A genome map is an ordering of a set of clones according to their believed position on a DNA string. Simple heuristics for genome map assembly based on single restriction enzyme with complete digestion data can lead to inaccuracies and ambiguities. This paper presents a method that adds additional constraint checking to the assembly process. An automaton is presented that for any genome map produces a refined genome map where both the clones and the restriction fragments in each clone are ordered satisfying natural constraints called step constraints. Any genome map that cannot be refined is highly likely to be inaccurate and can be eliminated as a possibility.
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Revesz, P.Z. Refining Restriction Enzyme Genome Maps. Constraints 2, 361–375 (1997). https://doi.org/10.1023/A:1009751730500
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DOI: https://doi.org/10.1023/A:1009751730500