Abstract
We have constructed a number of benzamidine- and butylamine-based hydantoin compounds by means of an efficient route using solid phase synthesis in which neat diisopropylamine was employed for a novel cyclization/traceless cleavage step. All library compounds were obtained in excellent yield and high purity.
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Wang resin (0.85 mmol/g) was purchased from Advanced ChemTech.
Each compound showed a single spot and peak by TLC and HPLC, respectively.
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Kim, S.W., Koh, J.S., Lee, E.J. et al. Solid phase synthesis of benzamidine and butylamine-derived hydantoin libraries. Mol Divers 3, 129–132 (1997). https://doi.org/10.1023/A:1009654016626
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DOI: https://doi.org/10.1023/A:1009654016626