Abstract
Hyperactivity has attracted a large amount of research interest in recent years. Here we review developments in genetic research and in research testing psychological theories of the condition. Family, adoptee and twin studies indicate a strong role for genetic factors in the etiology of hyperactivity. Evidence is emerging also from molecular genetic studies, implicating specific genes that may be involved. At the level of cognitive functioning, a divided, focused or sustained attention deficit does not seem to be a ‘core’ deficit in hyperactivity. Although children with hyperactivity often perform poorly on certain executive function tasks, there is disagreement about the interpretation of these findings. The association reported in some studies between a slow inhibitory process and hyperactivity may reflect a generally slow, variable in speed and inaccurate pattern of responding. Hypotheses about psychological mechanisms such as state regulation or delay aversion provide alternative, and particularly encouraging, interpretations of the findings. We discuss the possible integration of the two lines of research—those of genetic research and research on psychological mechanisms.
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REFERENCES
Alberts-Corush, J., Firestone, P., & Goodman, J. T. (1986). Attention and impulsivity characteristics of the biological and adoptive parents of hyperactive and normal control children. American Journal of Orthopsychiatry, 56, 413-423.
Aman, C. J., Roberts, R. J., & Pennington, B. F. (1998). A neuropsychological examination of the underlying deficit in ADHD: frontal lobe versus right parietal lobe theories. Developmental Psychology, 34, 956-969.
Barkley, R. A. (1994). Impaired delayed responding: A unified theory of attention-deficit hyperactivity disorder. In D. K. Routh (Ed.), Disruptive behavior disorders in childhood (pp. 11-57). New York: Plenum Press.
Barkley, R. A. (1997). Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121, 65-94.
Benjamin, J., Li, L., Patterson, C., Greenberg, B. D., Murphy, D. L., & Hamer, D. H. (1996). Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nature Genetics, 12, 81-84.
Biederman, J., Faraone, S. V., Keenan, K., Benjamin, J., Krifcher, B., Moore, C., Sprich-Buckminster, S., Ugaglia, K., Jellinek, M. S., Steingard, R., Spencer, T., Norman, D., Kolodny, R., Kruas, I., Perrin, J., Keller, M. B., & Tsuang M. T. (1992). Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder. Patterns of comorbidity in probands and relatives of psychiatrically and pediatrically referred samples. Archives of General Psychiatry, 49, 728-738.
Biederman, J., Faraone, S. V., Keenan, K., Knee, D., & Tsuang, M. T. (1990). Family-genetic and psychosocial risk factors in DSM-III attention deficit disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 526-533.
Biederman, J., Munir, K., Knee, D., Habelow, W., Armentano, M., Autor, S., Hoge, S. K., & Waternaux, C. (1986). A family study of patients with Attention Deficit Disorder and normal controls. Journal of Psychiatric Research, 20, 263-274.
Cantwell, D. P. (1972). Psychiatric illness in the families of hyperactive children. Archives of General Psychiatry, 414-417.
Cardon, L. R., Smith, S. D., Fulker, D. W., Kimberling, W. J., Pennington, B. F., & DeFries, J. C. (1994). Quantitative trait locus for reading-disability on chromosome-6. Science, 266, 276-279.
Cardon, L. R., Smith, S. D., Fulker, D. W., Kimberling, W. J., Pennington, B. F., & DeFries, J. C. (1995). Quantitative trait locus for reading disability: Correction. Science, 268.
Carte, E. T., Nigg, J. T., & Hinshaw, S. P. (1996). Neuropsychological functioning, motor speed, and language processing in boys with and without ADHD. Journal of Abnormal Child Psychology, 24, 481-498.
Castellanos, F. X., Lau, E., Tayebi, N., Lee, P., Long, R. E., Giedd, J. N., Sharp, W., Marsh, W. L., Walter, J. M., Hamburger, S. D., Ginns, E. I., Rapoport, J. L., & Sidransky, E. (1998). Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses. Molecular Psychiatry, 3, 431-434.
Castles, A., Datta, H., Gayan, J., & Olson, R. K. (1999). Varieties of developmental reading disorder: genetic and environmental influences. Journal of Experimental Child Psychology, 72, 73-94.
Cohen, J. D., & Servan-Schreiber, D. (1992). Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia. Psychological Review, 99, 45-77.
Cook, E. H. J., Stein, M. A., Krasowski, M. D., Cox, N. J., Olkon, D. M., Kieffer, J. E., & Leventhal, B. L. (1995). Association of attention-deficit disorder and the dopamine transporter gene. American Journal of Human Genetics, 56, 993-998.
Corkum, P. V., & Siegel, L. S. (1993). Is the continuous performance task a valuable research tool for use with children with attention-deficit hyperactivity disorder? Journal of Child Psychology and Psychiatry, 34, 1217-1239.
Craddock, N., & Owen, M. J. (1996). Modern molecular genetic approaches to psychiatric disease. British Medical Bulletin, 52, 434-452.
Daugherty, T. K., Quay, H. C., & Ramos, L. (1993). Response perseveration, inhibitory control, and central dopaminergic activity in childhood behavior disorders. The Journal of Genetic Psychology, 154, 177-188.
DeFries, J. C., & Fulker, D. W. (1985). Multiple regression analysis of twin data. Behavior Genetics, 15, 467-473.
DeFries, J. C., & Fulker, D. W. (1988). Multiple regression analysis of twin data: Etiology of deviant scores versus individual differences. Acta Geneticae Medicae et Gemellolologiae, 37, 205-216.
DeFries, J. C., Fulker, D. W., & LaBuda, M. C. (1987). Evidence for a genetic aetiology in reading disability of twins. Nature, 329, 537-539.
Douglas, V. I., & Parry, P. A. (1983). Effects of reward on delayed reaction time task performance of hyperactive children. Journal of Abnormal Psychology, 11, 313-326.
Downey, K. K., Stelson, F. W., Pomerleau, O. F., & Giordani, B. (1997). Adult attention deficit hyperactivity disorder: psychological test profiles in a clinical population. Journal of Nervous and Mental Disease, 185, 32-38.
Draeger, S., Prior, M., & Sanson, A. (1986). Visual and auditory attention performance in hyperactive children: competence or compliance. Journal of Abnormal Child Psychology, 14, 411-424.
Eaves, L. J., Silberg, J. L., Meyer, J. M., Maes, H. H., Simonoff, E., Pickles, A., Rutter, M., Neale, M. C., Reynolds, C. A., Erikson, M. T., Heath, A. C., Loeber, R., Truett, K. R., & Hewitt, J. (1997). Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. Journal of Child Psychology and Psychiatry, 38, 965-980.
Ebstein, R. P., Nemanov, L., Klotz, I., Gritsenko, I., & Belmaker, R. H. (1997). Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking. Molecular Psychiatry, 2, 472-477.
Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E. R., Nemanov, L., Katz, M., & Belmaker, R. H. (1996). Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nature Genetics, 12, 78-80.
Edelbrock, C., Rende, R., Plomin, R., & Thompson, L. A. (1995). A twin study of competence and problem behavior in childhood and early adolescence. Journal of Child Psychology and Psychiatry, 36, 775-785.
Faraone, S. V., Biederman, J., Jetton, J. G., & Tsuang, M. T. (1997). Attention deficit disorder and conduct disorder: Longitudinal evidence for a familial subtype. Psychological Medicine, 27, 291-300.
Faraone, S. V., Biederman, J., Keenan, K., & Tsuang, M. T. (1991a). Separation of DSM-III attention deficit disorder and conduct disorder: Evidence from a family-genetic study of American child psychiatric patients. Psychological Medicine, 21, 109-121.
Faraone, S. V., Biederman, J., Keenan, K., & Tsuang, M. T. (1991b). A family-genetic study of girls with DSM-III attention deficit disorder. American Journal of Psychiatry, 148, 112-117.
Faraone, S. V., Biederman, J., Weiffenbach, B., Keith, T., Chu, M. P., Weaver, A., Spencer, T. J., Wilens, T. E., Frazier, J., Cleves, M., & Sakai, J. (1999). Dopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder. American Journal of Psychiatry, 156, 768-770.
Gill, M., Daly, G., Heron, S., Hawi, Z., & Fitzgerald, M. (1997). Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Molecular Psychiatry, 2, 311-313.
Gillis, J. J., Gilger, J. W., Pennington, B. F., & DeFries, J. C. (1992). Attention deficit disorder in reading-disabled twins: Evidence for a genetic etiology. Journal of Abnormal Child Psychology, 20, 303-315.
Gjone, H., Stevenson, J., & Sundet, J. M. (1996). Genetic influence on parent-reported attention-related problems in a Norwegian general population twin sample. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 588-596.
Goodman, R., & Stevenson, J. (1989a). A twin study of hyperactivity-I. An examination of hyperactivity scores and categories derived from Rutter Teacher and Parent Questionnaires. Journal of Child Psychology and Psychiatry, 30, 671-689.
Goodman, R., & Stevenson, J. (1989b). A twin study of hyperactivity-II. The aetiological role of genes, family relationships and perinatal adversity. Journal of Child Psychology and Psychiatry, 30, 691-709.
Gorenstein, E. E., Mammato, C. A., & Sandy, J. M. (1989). Performance of inattentive-overactive children on selected measures of prefrontal-type function. Journal of Clinical Psychology, 45, 619-632.
Grigorenko, E. L., Wood, F. B., Meyer, M. S., Hart, L. A., Speed, W. C., Shuster, A., & Pauls, D. L. (1997). Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15. American Journal of Human Genetics, 60, 27-39.
Grigorenko, E. L., Wood, F. B., Meyen, M. S., Pauls, J. E. D., Hart, L. A., & Pauls, D. L. (1998). Linkage studies suggest a possible locus for dyslexia near the rh region on chromosome. Behavior Genetics, 28, 470.
Hohnen, B., & Stevenson, J. (1999). The structure of genetic influences on general cognitive, language, phonological, and reading abilities. Developmental Psychology, 35, 590-603.
Hudziak, J. J., Heath, A. C., Madden, P. F., Reich, W., Bucholz, K. K., Slutske, W., Bierut, L. J., Neuman, R. J., & Todd, R. D. (1998). Latent class and factor analysis of DSM-IV ADHD: a twin study of female adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 848-857.
Jennings, J. R., van der Molen, M. W., Pelham, W., Debski, K., & Hoza, B. (1997). Inhibition in boys with attention deficit hyperactivity disorder as indexed by heart rate change. Developmental Psychology, 33, 308-318.
Jönsson, E. G., Nöthen, M. M., Gustavsson, P., Neidt, H., Brené, S., Tylec, A., Propping, P., & Sedvall, G. C. (1997). Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms. American Journal of Psychiatry, 154, 697-699.
Kasius, M. C., Ferdinand, R. F., van den Berg, H., & Verhulst, F. C. (1997). Associations between different diagnostic approaches to child and adolescent psychopathology. Journal of Child Psychology and Psychiatry, 38, 625-632.
Kuntsi, J., Oosterlaan, J., & Stevenson, J. (1999). Psychological mechanisms in hyperactivity: I Response inhibition deficit, working memory impairment, delay aversion or something else? Submitted for publication.
Kuntsi, J., & Stevenson, J. (1999). Psychological mechanisms in hyperactivity: II Mediators of genetic effects. Submitted for publication.
LaHoste, G. J., Swanson, J. M., Wigal, S. B., Glabe, C., Wigal, T., King, N., & Kennedy, J. L. (1996). Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Molecular Psychiatry, 1, 121-124.
Levy, F., Hay, D., McStephen, M., Wood, C., & Waldman, I. (1997). Attention-deficit hyperactivity disorder: A category or a continuum? Genetic analysis of a large-scale twin study. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 737-744.
Logan, G. D. (1994). On the ability to inhibit thought and action: Ausers' guide to the stop signal paradigm. In D. Dagenbach & T. H. Carr (Eds.), Inhibitory processes in attention, memory, and language (pp. 189-239). San Diego: Academic Press.
Logan, G. D., & Cowan, W. B. (1984). On the ability to inhibit thought and action: A theory of an act of control. Psychological Review, 91, 295-327.
Logan, G. D., Cowan, W. B., & Davis, K. A. (1984). On the ability to inhibit simple and choice reaction time responses: A model and a method. Journal of Experimental Psychology, 10, 276-291.
Losier, B. J., McGrath, J., & Klein, R. M. (1996). Error patterns on the continuous performance test in non-medicated and medicated samples of children with and without ADHD: A meta-analytic review. Journal of Child Psychology and Psychiatry, 37, 971-987.
Malhotra, A. K., Virkkunen, M., Rooney, W., Eggert, M., Linnoila, M., & Goldman, D. (1996). The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and Novelty Seeking. Molecular Psychiatry, 1, 388-391.
Mariani, M. A., & Barkley, R. A. (1997). Neuropsychological and academic functioning in preschool boys with attention deficit hyperactivity disorder. Developmental Neuropsychology, 13, 111-129.
McGee, R., Williams, S., Moffitt, T., & Anderson, J. (1989). A comparison of 13-year-old boys with attention deficit and/or reading disorder on neuropsychological measures. Journal of Abnormal Child Psychology, 17, 37-53.
McGuffin, P., Owen, M. J., O'Donovan, M. C., Thapar, A., & Gottesman, I. J. (1994). Seminars in psychiatric genetics. London: Gaskell/Royal College of Psychiatrists.
McMahon, R. C. (1980). Genetic etiology in the hyperactive child syndrome: A critical review. American Journal of Orthopsychiatry, 50, 145-150.
Morrison, J., & Stewart, M. A. (1971). A family study of the hyperactive child syndrome. Biological Psychiatry, 3, 189-195.
Nadder, T. S., Silberg, J. L., Eaves, L. J., Maes, H. H., & Meyer, J. M. (1998). Genetic effects on ADHD symptomatology in 7-to 13-year-old twins: results from a telephone survey. Behavior Genetics, 28, 83-99.
Nigg, J. T., Swanson, J. M., & Hinshaw, S. P. (1997). Covert visual spatial attention in boys with attention deficit hyperactivity disorder: Lateral effects, methylphenidate response and results for parents. Neuropsychologia, 35, 165-176.
Närhi, V., & Ahonen, T. (1995). Reading disability with and without attention deficit hyperactivity disorder: Do attentional problems make a difference? Developmental Neuropsychology, 11, 337-349.
Olson, R., Wise, B., Conners, F., Rack, J., & Fulker, D. W. (1989). Specific deficits in component reading and language skills: genetic and environmental influences. Journal of Learning Disabilities, 22, 339-348.
Oosterlaan, J., Logan, G. D., & Sergeant, J. A. (1998). Response inhibition in AD/HD, CD, comorbid AD/HD+CD, anxious, and control children: A meta-analysis of studies with the stop task. Journal of Child Psychology and Psychiatry, 39, 411-425.
Oosterlaan, J., & Sergeant, J. A. (1996). Inhibition in ADHD, aggressive, and anxious children: A biologically based model of child psychopathology. Journal of Abnormal Child Psychology, 24, 19-36.
Oosterlaan, J., & Sergeant, J. A. (1998). Response inhibition and response reengagement in attention-deficit/hyperactivity disorder, disruptive, anxious and normal children. Behavioural Brain Research, 94, 33-43.
Palmer, C. G. S., Bailey, J. N., Ramsey, C., Cantwell, D., Del'Homme, M., McGough, J., Woodward, J. A., Asarnow, R., Asarnow, J., Smalley, S. L., & Nelson, S. (1999). Possible evidence of DAT1 gene by sex interaction in susceptibility to dopamine transporter. American Journal of Medical Genetics, 74, 630-631 (Abstract).
Pennington, B. F. (1994). The working memory function of the prefrontal cortices: Implications for developmental and individual differences in cognition. In M. M. Haith, J. B. Benson, R. J. Roberts Jr, & B. F. Pennington (Eds.), The development of future-oriented processes (pp. 243-289). Chicago: The University of Chicago Press.
Pennington, B. F., Bennetto, L., McAleer, O., & Roberts, R. J. Jr. (1996). Executive functions and working memory. In G. R. Lyon & N. A. Krasnegor (Eds.), Attention, memory, and executive function (pp. 327-348). Baltimore: Paul H. Brookes Publishing Co.
Pennington, B. F., & Ozonoff, S. (1996). Executive functions and developmental psychopathology. Journal of Child Psychology and Psychiatry, 37, 51-87.
Perrin, S., & Last, C. G. (1996). Relationship between ADHD and anxiety in boys: Results from a family study. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 988-996.
Pliszka, S. R., & Borcherding, S. H. The stop signal task in children with attention deficit hyperactivity disorder and anxiety. Unpublished manuscript.
Plomin, R., DeFries, J. C., McClearn, G. E., & Rutter, M. (1997). Behavioral genetics (3rd ed.). New York: W H Freeman.
Pribram, K. H., & McGuinness, D. (1975). Arousal, activation and effort in the control of attention. Psychological Review, 2, 116-149.
Quay, H. C. (1988). The behavioral reward and inhibition system in childhood behavior disorder. In L. M. Bloomingdale (Ed.), Attention deficit disorder: New research in attention, treatment and psychopathology (pp. 176-186). Oxford: Pergamon Press.
Quay, H. C. (1997). Inhibition and attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 25, 7-13.
Rabin, M., Wen, X. L., Hepburn, M., Lubs, H. A., Feldman, E., & Duara, R. (1993). Suggestive linkage of developmental dyslexia to chromosome 1p34-p36. Lancet, 342, 178.
Rhee, S. H., Waldman, I. D., Hay, D. A., & Levy, F. (1999). Sex differences in genetic and environmental influences on DSMIII-R Attention-Deficit/Hyperactivity Disorder. Journal of Abnormal Psychology, 108, 24-41.
Roberts, R. J., Hager, L., & Heron, C. (1994). Prefrontal cognitive processes: working memory and inhibition in the Antisaccade task. Journal of Experimental Psychology: General, 23, 374-393.
Roizen, N. J., Blondis, T. A., Irwin, M., Rubinoff, A., Kieffer, J., & Stein, M. A. (1996). Psychiatric and developmental disorders in families of children with attention-deficit hyperactivity disorder. Archives of Pediatric and Adolescent Medicine, 150, 203-208.
Rowe, D. C., Stever, C., Giedinghagen, L. N., Gard, J. M. C., Cleveland, H. H., Terris, S. T., Mohr, J. H., Sherman, S., Abramowitz, A., & Waldman, I. D. (1998). Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder. Molecular Psychiatry, 3, 419-426.
Sanders, A. F. (1983). Toward amodel of stress and human performance. Acta Psychologica, 53, 61-97.
Schachar, R., & Logan, G. D. (1990). Impulsivity and inhibitory control in normal development and childhood psychopathology. Developmental Psychology, 26, 710-720.
Schachar, R., & Tannock, R. (1995). Test of four hypotheses for the comorbidity of attention-deficit hyperactivity disorder and conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 639-648.
Schachar, R., Tannock, R., Marriott, M., & Logan, G. (1995). Deficient inhibitory control in attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 23, 411-437.
Schachar, R., & Wachsmuth, R. (1990). Hyperactivity and parental psychopathology. Journal of Child Psychology and Psychiatry, 31, 381-392.
Schweitzer, J. B., & Sulzer-Azaroff, B. (1995). Self-control in boys with attention deficit hyperactivity disorder: Effects of added stimulation and time. Journal of Child Psychology and Psychiatry, 36, 671-686.
Schulte-Korne, G., Grimm, T., Nothen, M. M., Muller Myhsok, B., Cichon, S., Vogt, I. R., Propping, P., & Remschmidt, H. (1998). Evidence for linkage of spelling disability to chromosome 15. American Journal of Medical Genetics, 63, 279-282.
Sergeant, J. A., Oosterlaan, J., & van der Meere, J. (1999). Information processing and energetic factors in attention-deficit/hyperactivity disorder. In H. C. Quay & Hogan (Eds.), Handbook of disruptive behavior disorders. New York: Plenum Press.
Sergeant, J. A., & van der Meere, J. J. (1989). The diagnostic significance of attentional processing: Its significance for ADDH classification-A future DSM. In T. Sagvolden & T. Archer (Eds.), Attention deficit disorder: Clinical and basic research. London: Lawrence Erlbaum Associates.
Sergeant, J. A., & van der Meere, J. J. (1990a). Convergence of approaches in localizing the hyperactivity deficit. In B. B. Lahey & A. E. Kazin (Eds.), Advances in clinical child psychology (pp. 207-246). New York: Plenum Press.
Sergeant, J. A., & van der Meere, J. J. (1990b). Additive factor method applied to psychopathology with special reference to childhood hyperactivity. Acta Psychologica, 74, 277-296.
Sergeant, J. A., & van der Meere, J. J. (1994). Toward an empirical child psychopathology. In D. K. Routh (Ed.), Disruptive behavior disorders in childhood (pp. 59-85). New York: Plenum Press.
Sherman, D. K., Iacono, W. G., & McGue, M. K. (1997). Attention deficit hyperactivity disorder dimensions: A twin study of inattention and impulsivity-hyperactivity. Journal of the American Academy of Child and Adolescent Psychiatry, 36 , 745-7
Sherman, D. K., McGue, M. K., & Iacono, W. G. (1997). Twin concordance for attention deficit hyperactivity disorder: A comparison of teachers' and mothers' reports. American Journal of Psychiatry, 154, 532-535.
Shue, K. L. & Douglas, V. I. (1992). Attention deficit hyperactivity disorder and the frontal lobe syndrome. Brain and Cognition, 20, 104-124.
Siegel, L. S. (1994). Working memory and reading: A life-span perspective. International Journal of Behavioral Development, 17, 109-124.
Siegel, L. S., & Ryan, E. B. (1989). The development of working memory in normally achieving and subtypes of learning disabled children. Child Development, 60, 973-980.
Simonoff, E., Pickles, A., Hervas, A., Silberg, J.-L., Rutter, M., & Eaves, L. (1998). Genetic influences on childhood hyperactivity: Contrast effects imply parental rating bias, not sibling interaction. Psychological Medicine, 28, 825-837.
Skuse, D. (1997). Genetic factors in the aetiology of child psychiatric disorders. Current Opinion in Pediatrics, 9, 354-360.
Smalley, S. L., Bailey, J. N., Palmer, C. G., Cantwell, D. P., McGough, J. J., Del'Homme, M. A., Asarnow, J. R., Woodward, J. A., Ramsey, C., & Nelson, S. F. (1998). Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder. Molecular Psychiatry, 3, 427-430.
Sonuga-Barke, E. J. S. (1994). Annotation: On dysfunction and function in psychological theories of childhood disorder. Journal of Child Psychology and Psychiatry, 35, 801-815.
Sonuga-Barke, E. J. S. (1995). Disambiguating inhibitory dysfunction in childhood hyperactivity. In J. Sergeant (Ed.), Eunethydis: European approaches to hyperkinetic disorder (pp. 209-223). Zurich: Fotorotar.
Sonuga-Barke, E. J. S. (1996). Debate and Argument: When ''impulsiveness'' is delay aversion; A reply to Schweitzer and Sulzer-Azaroff (1995). Journal of Child Psychology and Psychiatry, vn 37, 1023-1025.
Sonuga-Barke, E. J. S., & Taylor, E. (1992). The effect of delay on hyperactive and non-hyperactive children's response times: A research note. Journal of Child Psychology and Psychiatry, 33, 1091-1096.
Sonuga-Barke, E. J. S., Taylor, E., & Heptinstall, E. (1992). Hyperactivity and delay aversion-II. The effects of self versus externally imposed stimulus presentation periods on memory. Journal of Child Psychology and Psychiatry, 33, 399-409.
Sonuga-Barke, E. J. S., Taylor, E., Sembi, S., & Smith, J. (1992). Hyperactivity and delay aversion-I. The effect of delay on choice. Journal of Child Psychology and Psychiatry, 33, 387-398.
Stevenson, J. (1991). Which aspects of processing text mediate genetic effects? Reading and Writing: An Interdisciplinary Journal, 3, 249-269.
Stevenson, J., Graham, P., Fredman, G., & McLoughlin, V. (1987). A twin study of genetic influences on reading and spelling ability and disability. Journal of Child Psychology and Psychiatry, 28, 229-247.
Sonuga-Barke, E. J. S., Williams, E., Hall, M., & Saxton, T. (1996). Hyperactivity and delay aversion III: The effect on cognitive style of imposing delay after errors. Journal of Child Psychology and Psychiatry, 37, 189-194.
Stevenson, J. (1992). Evidence for a genetic etiology in hyperactivity in children. Behavior Genetics, 22, 337-344.
Swanson, J., Castellanos, F. X., Murias, M., LaHoste, G., & Kennedy, J. (1998). Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder. Current Opinion in Neurobiology, 8, 263-271.
Swanson, J. M., Sunohara, G. A., Kennedy, J. L., Regino, R., Fineberg, E., Wigal, T., Lerner, M., Williams, L., LaHoste, G. J., & Wigal, S. (1998). Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach. Molecular Psychiatry, 3, 38-41.
Tannock, R. (1998). Attention deficit hyperactivity disorder: Advances in cognitive, neurobiological, and genetic research. Journal of Child Psychology and Psychiatry, 39, 65-99.
Tannock, R., Ickowicz, A., & Schachar, R. (1995). Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 886-896.
Tannock, R., Schachar, R., Carr, R. P., Chajczyk, D., & Logan, G. D. (1989). Effects of methylphenidate on inhibitory control in hyperactive children. Journal of Abnormal Child Psychology, 17, 473-491.
Tannock, R., Schachar, R., & Logan, G. (1995). Methylphenidate and cognitive flexibility: Dissociated dose effects in hyperactive children. Journal of Abnormal Child Psychology, 23, 235-266.
Thapar, A., Hervas, A., & McGuffin, P. (1995). Childhood hyperactivity scores are highly heritable and show sibling competition effects: Twin study evidence. Behavior Genetics, 25, 537-544.
Thapar, A., Holmes, J., Poulton, K., & Harrington, R. (1999). Genetic basis of attention deficit and hyperactivity. British Journal of Psychiatry, 174, 105-111.
Tucker, D. M., & Williamson, P. A. (1984). Asymmetric neural control systems in human self regulation. Psychological Review, 91, 185-215.
van den Oord, E. J. C. G., Boomsma, D. I., & Verhulst, F. C. (1994). A study of problem behaviors in 10-to 15-year-old biologically related and unrelated international adoptees. Behavior Genetics, 24, 193-205.
van den Oord, E. J. C. G., Verhulst, F. C., & Boomsma, D. I. (1996). A genetic study of maternal and paternal ratings of problem behaviors in 3-year-old twins. Journal of Abnormal Psychology, 105, 349-357.
van der Meere, J. (1996). The role of attention. In S. Sandberg (Ed.), Hyperactivity disorders of childhood (pp. 111-148). Cambridge: Cambridge University Press.
van der Meere, J., Gunning, B., & Stemerdink, N. (1999). The effect of methylphenidate and clonidine on response inhibition and state regulation in children with ADHD. Journal of Child Psychology and Psychiatry, 40, 291-298.
van der Meere, J., & Sergeant, J. A. (1988). Controlled processing and vigilance in hyperactivity: Time will tell. Journal of Abnormal Child Psychology, 16, 641-655.
van der Meere, J., Shalev, R., Börger, N., & Gross-Tsur, V. (1995). Sustained attention, activation and MPH in ADHD: A research note. Journal of Child Psychology and Psychiatry, 36, 697-703.
van der Meere, J., Stemerdink, N., & Gunning, B. (1995). Effects of presentation rate of stimuli on response inhibition in ADHD children with and without tics. Perceptual and Motor Skills, 81, 259-262.
Vandenbergh, D. J., Zonderman, A. B., Wang, J., Uhl, G. R., & Costa Jr, P. T. (1997). No association between Novelty Seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants. Molecular Psychiatry, 2, 417-419.
Waldman, I. D., Rowe, D. C., Abramowitz, A., Kozel, S. T., Mohr, J. H., Sherman, S. L., Cleveland, H. H., Sanders, M. L., Gard, J. M. C., & Stever, C. (1998). Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. American Journal of Human Genetics, 63, 1767-1776.
Welsh, M. C., & Pennington, B. F. (1988). Assessing frontal lobe functioning in children: views from developmental psychology. Developmental Neuropsychology, 4, 199-230.
Willerman, L. (1973). Activity level and hyperactivity in twins. Child Development, 44, 288-293.
Zahn-Waxler, C., Schmitz, S., Fulker, D., Robinson, J., & Emde, R. (1996). Behavior problems in 5-year-old monozygotic and dizygotic twins: Genetic and environmental influences, patterns of regulation, and internalization of control. Development and Psychopathology, 8, 103-122.
Zentall, S. S., & Zentall, T. R. (1983). Optimal stimulation: A model of disordered activity and performance in normal and deviant children. Psychological Bulletin, 94, 446-471.
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Kuntsi, J., Stevenson, J. Hyperactivity in Children: A Focus on Genetic Research and Psychological Theories. Clin Child Fam Psychol Rev 3, 1–23 (2000). https://doi.org/10.1023/A:1009580718281
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DOI: https://doi.org/10.1023/A:1009580718281