Abstract
It is shown that γ-irradiation has remote consequences for mammalian cells cultivated in vitro. Many generations in the progeny of cells surviving acute and chronic irradiation at high and low doses are characterized by a number of abnormalities, including delayed cell death, the formation of micronuclei and giant cells, an increased frequency of sister chromatid exchanges, a reduced potential for repair, the loss of adaptive response, and increased radiosensitivity. These phenomena are regarded as manifestations of genomic instability induced by ionizing radiation.
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Pelevina, I.I., Gotlib, V.Y., Kudryashova, O.V. et al. Remote Consequences of Irradiation for the Progeny of Mammalian Cells. Russian Journal of Developmental Biology 32, 44–50 (2001). https://doi.org/10.1023/A:1009461127114
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DOI: https://doi.org/10.1023/A:1009461127114