Biotechnology Techniques

, Volume 12, Issue 7, pp 529–532 | Cite as

Production and purification of statins from Aspergillus terreus strains

  • Matilde Manzoni
  • Manuela Rollini
  • Silvia Bergomi
  • Valeria Cavazzoni


Lovastatin, mevastatin, pravastatin and monacolin J were produced using Aspergillus terreus strains. Mevastatin (170 mg/l) was obtained at 14 days from the A1 strain, lovastatin (256 mg/l) at 21 days from the A2 strain and pravastatin (270-300 mg/l) at 14 days from both the A1 and A2 strains grown on defatted soybean flour. Similar yields of monacolin J (5-10 mg/l) were detected for both strains. Fermentation carried out by adding glycerol to A1 7-d old cultures gave 244 mg lovastatin/l at 14 days employing whole soybean flour. A new extraction procedure was applied to an A2 19-d old culture on the mycelium and the culture filtrate separately. Recovery yield showed that 83% lovastatin was associated with the mycelium and 17% was free in the culture filtrate. © Rapid Science Ltd. 1998


Purification Fermentation Glycerol Aspergillus Extraction Procedure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Alberts, AW (1988). Amer J Cardiol62: 10J–15J.Google Scholar
  2. Alberts, AW, Chen, J, Kuron, G and Hunt, V (1980). Proc Natl Acad Sci USA77: 3957-3961.Google Scholar
  3. Buckland, B, Gbewonyo, K, Hallada, T, Kaplan, L and Masurekar, P (1989). Production of lovastatin, an inhibitor of cholesterol accumulation in humans. In: Novel Microbial product for Medicine and Agriculture, AL Demain, GA Somkuti, JC Hunter-Cevera and HW Rossmore, eds pp. 161-169, Amsterdam: Elsevier.Google Scholar
  4. Clark Still, W, Kahn, M and Mitra, A (1978). J Org Chem43: 2923-2925.Google Scholar
  5. Endo, A, Kuroda, M and Tsujita, Y (1976). J Antibiot29: 1346-1348.Google Scholar
  6. Juzlová, P, Martínková, L, and Kren, V (1996). J Ind Microbiol16: 163-170.Google Scholar
  7. Negishi, S, Cai-Huang, Z, Hasumi, K, Murakawa, S and Endo, A (1986) (in Japanese). Hakko Kogaku Kaishi 64: 509–512Google Scholar

Copyright information

© Chapman and Hall 1998

Authors and Affiliations

  • Matilde Manzoni
  • Manuela Rollini
  • Silvia Bergomi
  • Valeria Cavazzoni

There are no affiliations available

Personalised recommendations