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Lovastatin Production from Aspergillus Terreus ATCC 20542 Under Various Vegetable Oils Used as Sole and Supplementary Carbon Sources

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Pharmaceutical Chemistry Journal Aims and scope

The effect of vegetable oils used as sole and supplementary carbon sources on the production of lovastatin by Aspergillus terreus ATCC 20542 and their biomass in submerged fermentation has been examined. Eleven different types of edible vegetable oils were tested including camellia tea oil, canola oil, coconut oil, corn oil, olive oil, palm olein oil, rice bean oil, safflower oil, sesame oil, soybean oil, and sunflower oil. All selected oils can improve the yield of target product at least 2 times. The maximum yield was 87.18 g/L with supplementary 1% w/v coconut oil, which was about 11 times higher than that obtained from the oil-free control. Fungal biomass was proportional to vegetable oil concentration, but an excessive concentration of oil resulted in a lower yield. Substitutions of coconut oil and soybean oil at any quantities for lactose used as sole carbon source showed very low concentrations of lovastatin. These findings indicate that vegetable oils can be used for supporting fungal growth more than the secondary metabolite production. It can be concluded that easily available vegetable oil is a very promising adjuvant for lovastatin production.

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Acknowledgements

The authors wish to acknowledge Miss Janya Riunkesorn for her assistance. This study was financially supported by the National Research Council of Thailand (NRCT) and the Research Funds from Government Budget, Naresuan University, Thailand (grant number. R2554B058).

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Authors and Affiliations

  1. Pharmaceutical Biotechnology Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand

    Pattana Sripalakit & Aurasorn Saraphanchotiwitthaya

  2. Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand

    Pattana Sripalakit

  3. Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand

    Aurasorn Saraphanchotiwitthaya

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  1. Pattana Sripalakit
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Correspondence to Pattana Sripalakit.

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Sripalakit, P., Saraphanchotiwitthaya, A. Lovastatin Production from Aspergillus Terreus ATCC 20542 Under Various Vegetable Oils Used as Sole and Supplementary Carbon Sources. Pharm Chem J 54, 302–309 (2020). https://doi.org/10.1007/s11094-020-02195-x

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  • DOI: https://doi.org/10.1007/s11094-020-02195-x

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