Abstract
Purpose. To assess the miscibility and phase behavior of binary blendsof hydroxypropylmethyl cellulose (HPMC) with hydroxypropylcellulose (HPC), methylcellulose (MC), and polyvinylpyrrolidone (PVP).
Methods. Polymer-polymer miscibility was assessed by measurementof the glass transition temperature (Tg) and the width of the glasstransition temperature (W-Tg), using modulated temperaturedifferential scanning calorimetry (MTDSC).
Results. HPMC K4M/PVP and HPMC E5/MC blends were miscibleas evidenced by a single, composition dependent, Tg throughout theentire composition range. HPMC/HPC blends were immiscible at allcompositions. For the miscible blends, the variation in Tg with blendcomposition was compared to the values predicted by the Fox andCouchman-Karasz equations. At intermediate blend compositions,HPMC K4M/PVP blends exhibited negative deviations from idealbehavior. The Tg of the HPMC E5/MC blends was found to followthe Fox equation. The W-Tg measurements of the miscible blends gaveevidence of phase separation at certain compositions.
Conclusions. MTDSC was shown to be a useful technique incharacterizing the interactions between some commonly used pharmaceuticalpolymers.
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Nyamweya, N., Hoag, S.W. Assessment of Polymer-Polymer Interactions in Blends of HPMC and Film Forming Polymers by Modulated Temperature Differential Scanning Calorimetry. Pharm Res 17, 625–631 (2000). https://doi.org/10.1023/A:1007585403781
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DOI: https://doi.org/10.1023/A:1007585403781