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Nuclease activity of mixed ligand complexes of copper(II) with heteroaromatic derivatives and picoline

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Abstract

New picoline adducts with carbamic acid [(furan-2-yl)methylene]hydrazide–CuII (CFMH) (1); thiocarbamic acid [(furan-2-yl)methylene]hydrazide–CuII (TFMH) (2); carbamic acid [(furan-2-yl)ethylidene]hydrazide–CuII (CFEH) (3), thiocarbamic acid [(furan-2-yl)ethylidene]hydrazide–CuII (TFEH) (4); carbamic acid [(thiophene-2-yl) methylene]hydrazide–CuII (CTMH) (5), thiocarbamic acid [(thiophene-2-yl)methylene]hydrazide–CuII (TTMH) (6), carbamic acid [(thiophene-2-yl)ethylidene]hydrazide–CuII (CTEH) (7), thiocarbamic acid [(thiophene-2-yl)ethylidene]hydrazide–CuII (TTEH) (8) have been prepared and characterized by analytical, i.r., electronic, e.s.r. and c.v. spectral data. The electronic spectra suggest distorted octahedral geometry for all the picoline adducts. E.s.r. g ∥ values lie between 2.251–2.286 at l.n.t. All the adducts undergo a quasi-reversible one-electron reduction in the range +0.47 to +0.51 V versus s.c.e., attributable to the CuIII/CuII redox couple. The electron transfer is much faster in the semicarbazone complexes than in the thiosemicarbazone complexes. All adducts showed increased nuclease activity in the presence of oxidant; the nuclease activity is compared with that of the parent copper(II) complexes.

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Authors and Affiliations

  1. Department of Chemistry, Sri Krishnadevaraya University, Anantpur, 515 003, India

    K. Hussain Reddy & P. Sambasiva Reddy

  2. School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India

    P. Ravindra Babu

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  1. K. Hussain Reddy
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  2. P. Sambasiva Reddy
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Reddy, K.H., Reddy, P.S. & Babu, P.R. Nuclease activity of mixed ligand complexes of copper(II) with heteroaromatic derivatives and picoline. Transition Metal Chemistry 25, 505–510 (2000). https://doi.org/10.1023/A:1007038514536

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