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Endotoxin-induced alterations in hepatic glucose-6-phosphatase activity and gene expression

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References

  1. Filkins JP, Comell RP: Depression of hepatic gluconeogenesis and the hypoglycemia of septic shock. Am J Physiol 228:778–781, 1974

    Google Scholar 

  2. Wolfe RR, Elahi D, Spitzer JJ: Glucose and lactate kinetics after endotoxin administration in dogs. Am J Physiol 232: E180–E185, 1977

    Google Scholar 

  3. Lang CH, Spolarics Z, Ottlakan A, Spitzer JJ: Effect of high-dose endotoxin on glucose production and utilization. Metabolism 42: 1351–1358, 1993

    Google Scholar 

  4. Nordlie Rc, Bode AM, Foster JD: Recent advances in hepatic glucose 6–phosphatase regulation and function. Proc Soc Exp Biol Med 203: 274–285, 1993

    Google Scholar 

  5. Lange AJ, Arguad D, El-Maghrabi MR, Pan W, Maitra SR, Pilkis SJ: Isolation of cDNA for the catalytic subunit of rat liver glucose-6–phosphatase: Regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP. Biochem Biophys Res Commun 201: 302–309, 1994

    Google Scholar 

  6. Maitra, SR, Pan W, Lange AJ, El-Maghrabi MR, Abumrad NN, Pilkis SJ: Glucose-6–phosphatase gene expression and activity are modulated in hemorrhagic shock: Evidence for a new heat sensitive activator. Biochem Biophys Res Commun 204: 716–724, 1994

    Google Scholar 

  7. Ardawi MSM, Ashy AA, Jamal YS, Khoja JM: Metabolic control of hepatic gluconeogenesis in response to sepsis. J Lab Clin Med 114: 579–566, 1992

    Google Scholar 

  8. Sayeed MM: Alteration in cellular calcium regulation in the liver in endotoxic shock. Am J Physiol 250: R883–R891, 1986

    Google Scholar 

  9. Sayeed MM, Maitra SR: Effect of diltiazem on altered cellular calcium regulation during endotoxic shock. Am J Physiol 253: R549–R554, 1987

    Google Scholar 

  10. Maitra SR, Pan W, Geller ER: Effect of diltiazem on altered glucose regulation during endotoxic shock. J Surg Res 55: 201–204, 1993

    Google Scholar 

  11. Lang G, Mchal G: D-glucose-6–phosphate and D-fructose-6–phosphate metabolites, carbohydrate metabolism. In: H.U. Bergmeyer (ed). Methods of Enzymatic Analysis. Academic Press, New York, 1974, pp 1316–1319

    Google Scholar 

  12. Bickerstaff GF, Burchell B: Studies on the purification of glucose-6–phosphatase from rabbit liver microsomes. Biochem Soc Trans 8: 389–390, 1980

    Google Scholar 

  13. Yoo-Warren H, Monahan JE, Short J, Short H, Bouzel A, Wynshaw-Doris A, Meisner HM, Samols D, Hanson RW: Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat. Proc Natl Acad Sci USA 80: 3656–3660, 1983

    Google Scholar 

  14. Feinberg AP, Vogelstein B: A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 137: 266–267, 1984

    Google Scholar 

  15. Haber BA, Chin S, Chuang E, Buikhuisen W, Naji A, Taub R: High levels of glucose-6–phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes. J Clin Invest 95: 832–841, 1995

    Google Scholar 

  16. Mithieux G, Vidal U, Zitoun C, Druni N, Daniele N, Minassian C: Glucose-6–phosphatase mRNA and activity are increased to the same extent in kidney and liver of diabetic rats. Diabetes 45: 891–896, 1996

    Google Scholar 

  17. Liu Z, Barrett EJ, Dalkin AC, Lwan AD, Chou JY: Effect of acute diabetes on rat hepatic glucose-6–phsophatase activity and its messenger RNA level. Biochem Biophys Res Commun 205: 680–686, 1994

    Google Scholar 

  18. Maitra SR, Gestring M, El-Maghrabi MR: Alterations in hepatic 6–phosphofructo-2–kinase/fructose-2,6–bisphosphatase and glucose-6–phosphatase gene expression following hemorrhagic hypotension and resuscitation. Shock 8: 385–388, 1997

    Google Scholar 

  19. McCallum RE, Berry LJ: Mouse liver fructose 1,6–diphosphatase and glucose-6–phosphatase activites after endotoxin poisoning. Infect Immun 6: 883–885, 1972

    Google Scholar 

  20. Yasmineh WD, Theologides A: Effect of tumor necrosis factor on enzymes of gluconeogenesis in the rat. Proc Soc Exp Biol Med 199: 97–103, 1992

    Google Scholar 

  21. Chang CK, Moskal SF, Sovenugopal KS, Schumer W: Altered levels of mRNA involving analysis of hepatic glucose metabolism in septic rats. Circ Shock 41: 35–39, 1993

    Google Scholar 

  22. Wang K, Deutschman CS, Clemens MC, DeMaio A: Reciprocal expression of phosphoenolpyruvate carboxykinase and acute phase genes during acute inflammation. Shock 3: 204–209, 1995

    Google Scholar 

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Authors and Affiliations

  1. Trauma Research Laboratory, Departments of Emergency Medicine and Surgery, State University of New York at Stony Brook, Stony Brook, NY, USA

    Subir R. Maitra, Mark L. Gestring, M. Raafat El-Maghrabi, Charles H. Lang & Mark C. Henry

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  1. Subir R. Maitra
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  2. Mark L. Gestring
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  3. M. Raafat El-Maghrabi
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  4. Charles H. Lang
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  5. Mark C. Henry
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Maitra, S.R., Gestring, M.L., El-Maghrabi, M.R. et al. Endotoxin-induced alterations in hepatic glucose-6-phosphatase activity and gene expression. Mol Cell Biochem 196, 79–83 (1999). https://doi.org/10.1023/A:1006970229704

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