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Myocardial preconditioning: Basic concepts and potential mechanisms

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Abstract

Preconditioning is a phenomenon, where brief periods of stress such as ischemia, heat shock or certain pharmacological agents make the heart tolerant to subsequent lethal ischemic injury. Preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-activated protein kinases, opening of ATP-sensitive potassium channel and expression of a number of protective proteins. In this review, the potential role of these mechanisms is discussed.

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  1. Eric Lipman Laboratories of Molecular and Cellular Cardiology, Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA

    Shinji Okubo, Lei Xi, Nelson L. Bernardo, Kazu-ichi Yoshida & Rakesh C. Kukreja

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  1. Shinji Okubo
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  2. Lei Xi
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  3. Nelson L. Bernardo
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  4. Kazu-ichi Yoshida
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Okubo, S., Xi, L., Bernardo, N.L. et al. Myocardial preconditioning: Basic concepts and potential mechanisms. Mol Cell Biochem 196, 3–12 (1999). https://doi.org/10.1023/A:1006949626070

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