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The effect of hexadecylphosphocholine on the degradation of mitochondrial phospholipids

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Abstract

Hexadecylphosphocholine (HePC) is known as antitumor agent but the mechanism has not yet been understood. In rat liver mitochondria its effect on phospholipid transformation has been studied by quantitative HPTLC and phosphorus determination. From the results it can be concluded that HePC influences the activities of phospholipase A2, phospholipase C, phospholipase D, and lysophospholipase A. The phospholipid transformation as well as the influence of HePC are affected by exogenous calcium ions. In the presence of calcium HePC has been found to inhibit enzyme activities, whereas in the absence of exogenous calcium ions enzymatic phospholipid transformations are activated or inhibited depending on HePC concentrations.

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Authors and Affiliations

  1. Department of Biophysics, Faculty of Biology, Tashkent State University, Tashkent, Uzbekistan

    Olga Vagina

  2. Neuromuscular Laboratory, Department of Neurology, Faculty of Medicine, Martin-Luther University Halle-Wittenberg, Kurt-Mothes-Strasse 3, Halle, Germany

    Frank Norbert Gellerich

  3. Department of Biochemistry/Biotechnology, Martin-Luther University Halle-Wittenberg, Kurt-Mothes-Strasse 3, Halle, Germany

    Renate Ulbrich-Hofmann

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  1. Olga Vagina
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  2. Frank Norbert Gellerich
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  3. Renate Ulbrich-Hofmann
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Vagina, O., Gellerich, F.N. & Ulbrich-Hofmann, R. The effect of hexadecylphosphocholine on the degradation of mitochondrial phospholipids. Mol Cell Biochem 183, 169–173 (1998). https://doi.org/10.1023/A:1006826122602

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