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High Dose Chemotherapy with Autologous Stem Cell Rescue in Adults with Malignant Primary Brain Tumors

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Abstract

High dose chemotherapy (HDCT) with autologous (bone marrow or peripheral blood) stem cell rescue (ASCR) has had success in the treatment of some malignant pediatric brain tumors. We report a series of adults enrolled in one of three HDCT and ASCR protocols for malignant primary brain tumors.

Overall toxic mortality was 18%; chemotherapy regimen, tumor type, and prior treatment did not predict transplant-related mortality. Patients over the age of 30 had a higher rate of toxic mortality. Patients with recurrent medulloblastoma had a significant improvement in long-term survival (median: 34 months) as compared with historical reports; two patients with glioblastoma survive beyond four years without progression, but overall, a significant improvement in long-term survival could not be demonstrated for malignant gliomas.

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Authors and Affiliations

  1. Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Lauren E. Abrey

  2. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Marc K. Rosenblum

  3. Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Esperanza Papadopoulos & Barrett H. Childs

  4. Department of Pediatrics and the Kaplan Comprehensive Cancer Center, New York University Medical Center, New York, NY, USA

    Jonathan L. Finlay

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  1. Lauren E. Abrey
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  2. Marc K. Rosenblum
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  3. Esperanza Papadopoulos
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  4. Barrett H. Childs
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  5. Jonathan L. Finlay
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Abrey, L.E., Rosenblum, M.K., Papadopoulos, E. et al. High Dose Chemotherapy with Autologous Stem Cell Rescue in Adults with Malignant Primary Brain Tumors. J Neurooncol 44, 147–153 (1999). https://doi.org/10.1023/A:1006383400353

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