Abstract
Purpose: To report a rare case of episcleral neurofibroma and discuss the possible differential diagnoses. Methods: Case report of a 36-year-old man who presented with a painless epibulbar mass of the left eye. We describe the clinical and histopathologic features of the tumour and compare it with other tumours which may have a similar clinical presentation. Results: An excisional biopsy of the tumour was performed. Histopathologic examination revealed the tumour to be an isolated episcleral neurofibroma. Conclusion: It is often difficult to clinically differentiate this tumour from other conditions. Because of the slow growth of neurofibromas and its slow risk of malignant transformation, these lesions may be observed periodically for progression. Surgical excision may be performed if the lesion is found to be progressively enlarging in size.
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References
Jakobiec FA, Jones IS. Neurogenic tumors. In: Jones IS, Jakobiec FA, eds): Diseases of the Orbit. Hagerstown, Md: Harper & Row 1979: 371-416.
Coleman DJ, Jack RL, Franzen LA. Neurogenic tumors of the orbit. Arch Ophthalmol 1972; 88: 380-4.
Henderson JW. Orbital tumors. 3rd ed., New York, Raven Press, 1994; 448.
Kennedy RE. An evaluation of 820 orbital cases. Trans Am Ophthalmol Soc 1984; 82: 1341-57.
Rose GE, Wright JE. Isolated peripheral nerve sheath tumours of the orbit. EYE 1991; 5: 668-73.
Shields JA, Sanborn GE, Kurz GH, Augsburger JJ. Benign peripheral nerve tumor of the choroid. A clinicopathologic correlation and review of the literature. Ophthalmology 1981; 88: 1322-9.
Krohel GB, Rosenberg MD, Wright JE, Smith RS. Localized orbital neurofibromas. Am J Ophthalmol 1972; 1985; 100: 458-64.
Perry HD. Isolated Episcleral Neurofibroma. Ophthalmol 1982; 89: 1095-8.
Rootman J, Goldberg C, Robertson W. Primary orbital Schwannomas. Br J Ophthalmol 1982; 66: 194-204.
Quintana M, Lee WR. Intrascleral Schwannoma. Ophthalmologica 1976; 173: 64-9.
Weiss SW, Langloss JM, Enzinger FM. Value of S-100 protein in the diagnosis of soft tissue tumours with particular reference to benign and malignant Schwann cell tumours. Lab Invest 1983; 49: 299-308.
Lyons CJ, McNab AA, Garner A, Wright JE. Orbital malignant peripheral nerve sheath tumours. Br J Ophthalmol 1989; 73: 731-8.
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Ang, L.PK., Heng, WJ. & Chan, WK. A Case of Episcleral Neurofibroma. Int Ophthalmol 22, 207–210 (1998). https://doi.org/10.1023/A:1006218728844
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DOI: https://doi.org/10.1023/A:1006218728844