Skip to main content
SpringerLink
Log in

Postoperative Radiotherapy for Supratentorial Malignant Gliomas

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

From January 1988 to December 1996, sixty-five patients with histologically confirmed supratentorial malignant gliomas were treated with postoperative radiation therapy in our department. They were subjected to this analysis according to different clinical and pathologic parameters. The overall 1-year, 2-year survival rate was 57% and 23%, respectively. With univariate analysis, age, postoperative Karnofsky performance status, duration of symptoms, multiplicity of lesions and the extent of surgery were identified as significant prognostic factors. With multivariate analysis, postoperative Karnofsky performance status and the extent of surgery continued to show independent prognostic significance on overall survival.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chang CH, Horton J, Schoenfeld D, Salazer O, Perez-Tamayo R, Kramer S, Weinstein A, Nelson JS, Tsukada Y: Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. Cancer 52: 997–1007, 1983

    Google Scholar 

  2. Shapiro WR: Therapy of adult malignant brain tumors: what have the clinical trials taught us? Semin Oncol 13: 38–45, 1986

    Google Scholar 

  3. Fine HA, Dear KB, Loeffler JS, Black PM, Canellos GP: Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71: 2585–2597, 1993

    Google Scholar 

  4. Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P: Grading of astrocytomas: A simple and reproducible method. Cancer 62: 2152–2165, 1988

    Google Scholar 

  5. Kaplan EL, Meier P: Nonparametric estimation for incomplete observation. J Am Stat Assoc 53: 457–481, 1958

    Google Scholar 

  6. Mantel N, Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. Natl Cancer Inst 22: 719–748, 1959

    Google Scholar 

  7. Cox DR: Regression models and life tables. J R Stat Soc 34: 187–220, 1972

    Google Scholar 

  8. Anonymous: Prognostic factors for high-grade malignant glioma: development of a prognostic index. A report of 187 the Medical Research Council Brain Tumor Working Party. J Neurooncol 9: 47–55, 1990

  9. Burger PC, Vogel FS, Green SB, Strike TA: Glioblastoma multiforme and anaplastic astrocytoma: pathologic criteria and prognostic implications. Cancer 56: 1106–1111, 1985

    Google Scholar 

  10. Scanlon PW, Taylor WF: Radiotherapy of intracranial astrocytomas: analysis of 417 cases treated from 1960 through 1969. Neurosurgery 5: 301–308, 1979

    Google Scholar 

  11. Nelson JS, Tsukada Y, Schoenfeld D, Fulling K, Lamarche J, Peress N: Necrosis as a prognostic criterion in malignant supratentorial astrocytic gliomas. Cancer 52: 550–554, 1983

    Google Scholar 

  12. Hochberg FH, Pruitt A: Assumptions in the radiotherapy of glioblastoma. Neurology 30: 907–911, 1980

    Google Scholar 

  13. Coffey RJ, Lunsford LD, Taylor FH: Survival after stereotactic biopsy of malignant gliomas. Neurosurgery 22: 465–473, 1988

    Google Scholar 

  14. Salcman M: Resection and reoperation in neuro-oncology: rationale and approach. Neuro Clin 3: 831–842, 1985

    Google Scholar 

  15. Ciric I, Ammirati M, Vick N, Mikhael M: Supratentorial gliomas: Surgical considerations and immediate postoperative results. Gross total resection versus partial resection. Neurosurgery 21: 21–26, 1987

    Google Scholar 

  16. Berger MS: Malignant astrocytomas: surgical aspects. Semin Oncol 21: 172–185, 1994

    Google Scholar 

  17. Garcia DM, Fulling KH, Marks JE: The value of radiation therapy in addition to surgery for astrocytomas of the adult cerebrum. Cancer 55: 919–927, 1985

    Google Scholar 

  18. Leibel SA, Sheline GE: Radiation therapy for neoplasms of the brain. J Neurosurg 66: 1–22, 1987

    Google Scholar 

  19. Walker MD, Green SB, Byar DP, Alexander E Jr, Batzdorf U, Brooks WH, Hunt WE, MacCarty CS, Mahaley MS Jr, Mealey J Jr, Owens G, Ransohoff J 2nd, Robertson JT, Shapiro WR, Smith KR Jr, Wilson CB, Strike TA: Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant gliomas after surgery. N Engl J Med 303: 1323–1329, 1980

    Google Scholar 

  20. Kristiansen K, Hagen S, Kollevold T, Torvik A, Holme I, Nesbakken R, Hatlevoll R, Lindgren M, Brun A, Lindgren S, Notter G, Andersen AP, Elgen K: Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multicenter trial of the Scandinavian Glioblastoma Study Group. Cancer 47: 649–652, 1981

    Google Scholar 

  21. Suit HD, Baumann M, Skates S, Convery K: Clinical interest in determinations of cellular radiation sensitivity. Int J Radiat Biol 56: 725–737, 1989

    Google Scholar 

  22. Salazar OM, Rubin P, McDonald JV, Feldstein ML: Patterns of failure in intracranial astrocytomas after irradiation: analysis of dose and field factors. Am J Roentgenol 126: 279–292, 1976

    Google Scholar 

  23. Choucair AK, Levin VA, Gutin PH, Davis RL, Silver P, Edwards MS, Wilson CB: Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas. J Neurosurg 65: 654–658, 1986

    Google Scholar 

  24. Garden AS, Maor MH, Yung WK, Bruner JM, Woo SY, Moser RP, Lee YY: Outcome and patterns of failure following limited-volume irradiation for malignant astrocytomas. Radiother Oncol 20: 99–110, 1991

    Google Scholar 

  25. Massey V, Wallner KE: Patterns of second recurrence of malignant astrocytomas. Int J Radiat Oncol Biol Phys 18: 395–398, 1990

    Google Scholar 

  26. Leibel SA, Scott CB, Loeffler JS: Contemporary approaches to the treatment of malignant gliomas with radiation therapy. Semin Oncol 21: 198–219, 1994

    Google Scholar 

  27. Wara WM, Bauman GS, Sneed PK, Larson DA, Karlsson UL: Brain, Brain Stem, and Cerebellum. In: Perez CA, Brady LW (eds) Principles and Practice of Radiation Oncology. 3rd edition. Lippincott-Raven Publishers, Philadelphia, PA, 1998, pp 800–801

    Google Scholar 

  28. Marks JE, Baglan RJ, Prassad SC, Blank WF: Cerebral radionecrosis: incidence and risk in relation to dose, time, fractionation and volume. Int J Radiat Oncol Biol Phys 7: 243–252, 1981

    Google Scholar 

  29. Miller PJ, Hassanein RS, Giri PGS, Kimler BF, O'Boynick P, Evans RG: Univariate and multivariate statistical analysis of high-grade gliomas: the relationship of radiation dose and other prognostic factors. Int J Radiat Oncol Biol 19: 275–280, 1990

    Google Scholar 

  30. Prados MD, Gutin PH, Phillips TL, Wara WM, Sneed PK, Larson DA, Lamb SA, Ham B, Malec MK, Wilson CB: Interstitial brachytherapy for newly diagnosed patients with malignant gliomas: the UCSF experience. Int J Radiat Oncol Biol Phys 24: 593–597, 1992

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan

    Shyh-An Yeh, Stephen Wan Leung, Li-Min Sun, Chong-Jong Wang, Fu-Min Fang & Hui-Chun Chen

Authors
  1. Shyh-An Yeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen Wan Leung
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Li-Min Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chong-Jong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Fu-Min Fang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hui-Chun Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yeh, SA., Leung, S.W., Sun, LM. et al. Postoperative Radiotherapy for Supratentorial Malignant Gliomas. J Neurooncol 42, 183–187 (1999). https://doi.org/10.1023/A:1006154413957

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1006154413957

Search

Navigation