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Kinematic analysis of left ventricular deformation in myocardial infarction using magnetic resonance cardiac tagging

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Abstract

The Magnetic Resonance (MR) tagging technique provides detailed information about 2D motion in the plane of observation. Interpretation of this information as a reflection of the 3D motion of the entire cardiac wall is a major problem. In finite element models of the mechanics of the infarcted heart, an infarcted region causes motional asymmetry, extending far beyond the infarct boundary. Here we present a method to quantify such asymmetry inamplitude and orientation. For this purpose images of a short-axis cross-section of the ejecting left ventricle were acquired from 9 healthy volunteers and 5 patients with myocardial infarction. MR-tags were applied in a 5 mm grid at end-diastole. The tags were tracked by video-image analysis. Tag motion was fitted to a kinematic model of cardiac motion. For the volunteers and the patients the center of the cavity displaced by about the same amount(p=0.11) during the ejection phase: 3.8 ± 1.4 and 3.0 ± 0.9 mm (mean ± sd), respectively. Cross-sectional rotation and the decrease in cross-sectional area of the cavity were both greater in the volunteers than in the patients: 6.4 ± 1.5 vs. 3.0 ± 0.8 degrees (p<0.001), and 945 ± 71 vs. 700 ± 176 mm 2 (p=0.02), respectively. In the patients, asymmetry of wall motion, as expressed by a sine wave dependency of contraction around the circumference, was significantly enlarged (p=0.02). The proposed method of kinematic analysis can be used to assess cardiac deformation in humans. We expect that by analyzing images of more cross-sections simultaneously, the 3D location and the degree of infarction can be assessed efficiently.

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Authors and Affiliations

  1. Departments of Biophysics, Cardiovascular Research Institute Maastricht, Maastricht Uni-versity, 6200 MD, Maastricht, The Netherlands

    Frank W.L. Aelen & Theo Arts

  2. Department of Diagnostic Radiology, University Hospital Maastricht, 6202 AZ, Maastricht, The Netherlands

    Dave G.M. Sanders & Guillaume R.P. Thelissen

  3. Departments of Physiology, Cardiovascular Research Institute Maastricht, Maastricht Uni-versity, 6200 MD, Maastricht, The Netherlands

    Frits W. Prinzen & Robert S. Reneman

Authors
  1. Frank W.L. Aelen
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  2. Theo Arts
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  3. Dave G.M. Sanders
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  4. Guillaume R.P. Thelissen
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  5. Frits W. Prinzen
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  6. Robert S. Reneman
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Aelen, F.W., Arts, T., Sanders, D.G. et al. Kinematic analysis of left ventricular deformation in myocardial infarction using magnetic resonance cardiac tagging. Int J Cardiovasc Imaging 15, 241–251 (1999). https://doi.org/10.1023/A:1006089820107

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  • DOI: https://doi.org/10.1023/A:1006089820107

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