Abstract
We studied a patient with juvenile pilocytic astrocytoma (JPA) using positron emission tomography (PET), 18 F-fluorodeoxyglucose (FDG),11 C-methionine (MET), and 82Rubidium (RUB). Non-linear fitting and multiple time graphical plotting of the dynamic PET data revealed values for tumor plasma volume, blood-brain barrier transport rate constants and tracer distribution volume in the range of glioblastomas and meningiomas, or higher. Likewise, the steady-state accumulation of MET and FDG was increased. With regard to the known vascular composition of JPA, our data suggest that increased transport and distribution considerably contribute to the high net tracer uptake observed in this tumor.
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Di Chiro G: Positron emission tomography using [18F] fluoro-deoxyglucose in brain tumors: A powerful diagnostic and prognostic tool. Invest Radiol 22: 360–371, 1986
Patronas NJ, Di Chiro GD, Kufta C, Bairamian D, Kornblith PL, Simon R, Larson SM: Prediction of survival in glioma patients by means of positron emission tomography. J Neurosurg 62: 816–822, 1985
Ericson K, Blomqvist G, Bergström M, Eriksson L, Stone-Elander S: Application of a kinetic model on the methionine accumulation in intracranial tumors studied with positron emission tomography. Acta Radiol 28: 505–509, 1987
Brooks DJ, Beaney R, Lammertsma AA, Leenders KL, Horlock PL, Kensett MJ, Marshal J, Thomas DG, Jones TJ: Quantitative measurement of blood-brain barrier permeability using Rubidium-82 and positron emission tomography. J Cereb Blood Flow Metab 4: 535–545, 1984
Palma L, Guidetti B: Cystic pilocytic astrocytomas of the cerebral hemispheres: surgical experience with 51 cases and long-term results. J Neurosurg 62: 811–815, 1985
Fulham MJ, Melisi JW, Nishimiya J, Dwyer AJ, Di Chiro G: Neuroimaging of juvenile pilocytic astrocytomas: An enigma. Radiology 189: 221–225, 1993
Patlak CS, Blasberg RG, Fenstermacher JD: Graphical evaluation of blood-to-brain transfer constants for multiple-time uptake data. J Cereb Blood Flow Metab 3: 1–7, 1983
Wesseling P, Vandersteenhoven JJ, Downey BT, Ruiter DJ, Burger PC: Cellular components of microvascular proliferation in human glial and metastatic brain neoplasms. A light microscopic and immunohistochemical study of formalin-fixed, routinely processed material. Acta Neuropathol 85: 508–514, 1993
Lombardi D, Scheithauer BW, Piepgras D, Meyer FB, Forbes GS: ‘Angioglioma’ and the arteriovenous malformation-glioma association. J Neurosurg 75: 589–566, 1991
Sato K, Rorke LB: Vascular bundles and wickerworks in childhood brain tumors. Pediatr Neurosci 15: 105–110, 1980
Greig NH: Brain tumors and the blood-brain barrier. In: Neuwelt EA (ed) Implications of the blood-brain barrier and its manipulation. Plenum Publ Corp, New York, Vol 2, pp. 77–106, 1989
Herholz K, Rudolf J, Heiss WD: FDG transport and phosphorylation in human gliomas measured with dynamic PET. J Neuro-Oncol 12: 159–165, 1992
Murovic JA, Nagashima T, Hoshino T, Edwards MS, Davis RL: Pediatric central nervous system tumors: a cell kinetic study with bromodeoxyuridine. Neurosurgery 19: 900–904, 1986
Guerin C, Laterra J, Hruban RH, Brem H, Drewes LR, Goldstein GW: The glucose transporter and blood-brain barrier of human brain tumors. Ann Neurol 28: 758–765, 1990
Harik SI, Roessmann U: The erythrocyte-type glucose transporter in blood vessels of primary and metastatic brain tumors. Ann Neurol 29: 487–491, 1991
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Roelcke, U., Radü, E., Hausmann, O. et al. Tracer transport and metabolism in a patient with juvenile pilocytic astrocytoma. A PET study. J Neurooncol 36, 279–283 (1998). https://doi.org/10.1023/A:1005898109520
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DOI: https://doi.org/10.1023/A:1005898109520