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Enantioselective esterification of 2-arylpropionic acids and trans-2-phenyl-1-cyclohexanol: Comparison between immobilised lipases from Candida rugosa and Rhizomucor miehei

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Abstract

2-Phenyl propionic acid, ibuprofen and trans-2-phenyl-1-cyclohexanol were resolved using commercial Rhizomucor miehei lipase (Lipozyme IM20) and Candida rugosa lipase produced in our laboratory immobilised on EP100 polypropylene powder. Important differences were found on the enantioselectivity of both lipases in esterification reactions. Candida rugosa lipase was more enantioselective in the resolution of the tested substrates, especially with trans-2-phenyl-1-cyclohexanol, whereas the lipase from Rhizomucor miehei did not show catalytic activity with this substrate. © Rapid Science Ltd. 1998

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Authors and Affiliations

  1. Departament d'Enginyeria Química. ETSE, Universitat Autònoma de Barcelona, Bellaterra, Spain

    Antoni Sánchez, Francisco Valero, Javier Lafuente & Carles Solà

Authors
  1. Antoni Sánchez
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  2. Francisco Valero
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  3. Javier Lafuente
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  4. Carles Solà
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Sánchez, A., Valero, F., Lafuente, J. et al. Enantioselective esterification of 2-arylpropionic acids and trans-2-phenyl-1-cyclohexanol: Comparison between immobilised lipases from Candida rugosa and Rhizomucor miehei. Biotechnology Letters 20, 1145–1148 (1998). https://doi.org/10.1023/A:1005328504095

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