Abstract
We have studied the reaction of 2-aminobenzimidazole with esters of substituted cinnamic acids and arylidene derivatives of Meldrum's acid, and have established the direction of formation of the tetrahydrooxopyrimidine ring. We have conducted an X-ray diffraction study of 2-phenyl-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-4-one.
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REFERENCES
E. Szarvasi, D. Festal, M. Grand, J. C. Depin, T. N. Luong, Eur. J. Med. Chem. Chim. Ther., 16, 327 (1981).
V. V. Lipson, S. M. Desenko, V. D. Orlov, E. N. Ryndina, A. V. Chuvurin, N. I. Gorbenko, and A. A. Kirichenko, Khim.-Farm. Zh., No. 2, 14 (1994).
S. M. Desenko, V. D. Orlov, V. V. Lipson, and H. Estrada, Khim. Geterotsikl. Soedin., 1215 (1991).
Dalal Abou El Ella, E. Gobnitzer, and W. Wendelin, J. Heterocycl. Chem., 33, 373 (1996).
A. A. Shazhenov and Ch. Sh. Kadyrov, Khim. Geterotsikl. Soedin., 1389 (1977).
S. M. Desenko, V. V. Lipson, O. V. Shishkin, S. A. Komykhov, V. D. Orlov, E. E. Lakin, V. P. Kuznetsov, and H. Meier, J. Heterocycl. Chem., 36, 205 (1999).
H.-B. Burgi and J. D. Dunitz, Structure Correlation, VCH, Weinheim (1994), Vol. 2, p. 741.
V. V. Lipson, V. D. Orlov, S. M. Desenko, T. M. Karnozhitskaya, and M. G. Shirobokova, Khim. Geterotsikl. Soedin., 664 (1999).
G. M. Sheldrick, SHELXTL PLUS. PC Version. A system of computer programs for the determination of crystal structure from X-ray diffraction data. Rev. 5.02.1994.
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Lipson, V.V., Orlov, V.D., Desenko, S.M. et al. 1,2,3,4-Tetrahydropyrimido[1,2-a]benzimidazol-2- and -4-Ones. Chemistry of Heterocyclic Compounds 36, 1039–1043 (2000). https://doi.org/10.1023/A:1002777714158
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DOI: https://doi.org/10.1023/A:1002777714158