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Fourth Annual Mario S. Verani, MD Memorial Lecture: Noninvasive imaging in coronary artery disease: Changing roles, changing players

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Journal of Nuclear Cardiology Aims and scope

Conclusion

This review has suggested that there is an interaction between the noninvasive assessment of coronary anatomic abnormality-through the CCS or coronary CTA-and the assessment of the functional consequences of disease by use of gated MPS, PET, or potentially, CMR. Additional information of clinical importance may come from the assessment of biomarkers of inflammation, such as high-sensitivity C-reactive protein50 or, more recently, lipoprotein-associated phospholipase A2,51 which appears to be even more specific for vascular inflammation. Given the strength of the evidence supporting the use of MPS and PET, the ease and effectiveness with which these approaches can be used in patients with known disease and in the elderly, and the great untapped potential of these approaches in molecular imaging, it is likely that there will continue to be growth for several years in the use of MPS and PET for assessing patients with known or suspected cardiovascular disease. It is imperative that physicians recognize the potential that overuse of expensive diagnostic testing could “break the bank,” resulting in controls of utilization that would lessen the beneficial impact of the powerful tools we are so fortunate to have available.

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Authors and Affiliations

  1. Departments of Imaging and Medicine, Division of Cardiology, Cedars-Sinai Medical Center, University of California, 8700 Beverly Blvd, Room 1258, 90048, Los Angeles, Los Angeles, Calif.

    Daniel S. Berman

  2. David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, Calif.

    Daniel S. Berman

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Berman, D.S. Fourth Annual Mario S. Verani, MD Memorial Lecture: Noninvasive imaging in coronary artery disease: Changing roles, changing players. J Nucl Cardiol 13, 457–473 (2006). https://doi.org/10.1016/j.nuclcard.2006.05.009

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