Abstract
This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism.
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TL and CJ wrote the manuscript. TL and GS carried out the data analyses. TL and CJ designed the study. The remaining authors contributed to refining the ideas, carrying out additional analyses and finalizing the paper. All the authors have read the final manuscript and approved submission.
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Lv, Tt., Ju, Cg., Liu, Bn. et al. Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study. Rev. Bras. Farmacogn. 29, 744–748 (2019). https://doi.org/10.1016/j.bjp.2019.08.005
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DOI: https://doi.org/10.1016/j.bjp.2019.08.005