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Electrospinning and crosslinking of COL/PVA Nanofiber-microsphere Containing Salicylic Acid for Drug Delivery

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Abstract

Porous nanofiber-microsphere mats of collagen (COL)/polyvinyl alcohol (PVA) containing salicylic acid (SA) as model drug were prepared by electrospinning for the assessment of drug delivery system. The electrospun fibrous mats were crosslinked by UV-radiation or glutaraldehyde to weaken the degree of drug burst release and morphology damage when meeting water. The morphology and chemical structures of COL/PVA-SA electrospun fibers were characterized by SEM and FTIR. The crosslinking of UV-radiation did not destroy the morphology of COL/PVA-SA electrospun fibers in the crosslinking process, however, the crosslinking of glutaraldehyde did it. In vitro release studies showed that COL/PVA-SA electrospun fibers efficiently controlled the release of drugs by the crosslinking of UV-radiation for 4 h. The transport mechanism that controlled the release of drugs from electrospun mats was Fickian diffusion.

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Authors and Affiliations

  1. College of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450001, China

    Xiaoli Zhang, Keyong Tang & Xuejing Zheng

  2. Henan Key Laboratory of Functional Textile Materials, College of Textiles, Zhongyuan University of Technology, Zhengzhou, 450007, China

    Xiaoli Zhang

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  1. Xiaoli Zhang
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  2. Keyong Tang
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Zhang, X., Tang, K. & Zheng, X. Electrospinning and crosslinking of COL/PVA Nanofiber-microsphere Containing Salicylic Acid for Drug Delivery. J Bionic Eng 13, 143–149 (2016). https://doi.org/10.1016/S1672-6529(14)60168-2

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