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A Novel Drug Delivery Carrier Based on α-eleostearic Acid Grafted Hydroxyapatite Composite

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Abstract

The purpose of this study is to explore and develop a novel biocompatibility drug delivery carrier for controllingontrolled drug release. The α-eleostearic acid grafted hydroxyapatite (α-ESA-g-HA) composite was synthesized by using silane coupling agent and characterized by Fourier Transformation Infrared Spectroscopy (FT-IR), Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscope (SEM), respectively. The in vitro drug loading and controlled release behaviors of α-ESA-g-HA composite were investigated using ciprofloxacin as the model drug. The amount of ciprofloxacin loading and released was calculated by absorbance value which was determined by UV-Vis spectrophotometry at wavelength of 277 nm. The biocompatibility of α-ESA-g-HA composite was assessed by 3-(4,5)-dimethylthiahiazo(-z-yl)-3,5-di-phenytetrazoliumromide(MTT) assay, nuclear morphology and platelet adhesion. The results showed that the α-ESA-g-HA had nontoxic and good biocompatibility. According to the results mentioned above, the α-ESA-g-HA is an effective drug delivery carrier, which could increase drug loading capacity and control drug release, so further studies are necessary to evaluate clinical application and human health care.

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Authors and Affiliations

  1. Key Laboratory of Synthetic and Natural Functional Molecular Chemistry of Ministry of Education, Northwest University, Xi’an, 710069, P. R. China

    Ting Cao, Weili Tang, Jingchan Zhao, Lulu Qin & Chunbo Lan

  2. College of Chemistry & Material Science, Northwest University, Xi’an, 710069, P. R. China

    Ting Cao, Weili Tang, Jingchan Zhao, Lulu Qin & Chunbo Lan

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  1. Ting Cao
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  2. Weili Tang
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  3. Jingchan Zhao
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  4. Lulu Qin
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  5. Chunbo Lan
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Correspondence to Jingchan Zhao.

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Cao, T., Tang, W., Zhao, J. et al. A Novel Drug Delivery Carrier Based on α-eleostearic Acid Grafted Hydroxyapatite Composite. J Bionic Eng 11, 125–133 (2014). https://doi.org/10.1016/S1672-6529(14)60027-5

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  • DOI: https://doi.org/10.1016/S1672-6529(14)60027-5

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