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Bovine serum albumin binding and drug delivery studies with PVA-ferrofluid

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Abstract

This paper describes a single-step method for the biomimetic synthesis of stably suspended magnetite nanoparticles in poly(vinyl alcohol) termed ferrofluids. The challenge is to synthesize water based stable magnetic colloids with a control over the particle size and morphology for biomedical applications. The polymer possibly plays a dual role of a surfactant and a functionalizing agent. Transmission electron microscopy, infrared spectroscopy and vibrating sample magnetometry were used to investigate the properties of the synthesized ferrofluids. It has a strong affinity towards the tryptophan residues in bovine serum albumin protein as determined from the fluorescence emission studies. For in vivo applications this could indirectly mean a resistance to immune response and thus ensure long-term circulation. The ability of the synthesized ferrofluid to bind a chemotherapeutic drug ceftriaxone and its ionic release was observed. The polymer hydroxyl group allows drug-binding and the magnetic property allows targeting to specific sites. Magnetic hybrid fluids with combined advantages of magnetism and polymer open up new perspectives for applications.

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Authors and Affiliations

  1. National Metallurgical Laboratory, Jamshedpur, 831007, India

    Suprabha Nayar, Aparna Mir, Aarti Ashok, Avijit Guha & Vikas Sharma

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  1. Suprabha Nayar
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  2. Aparna Mir
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  3. Aarti Ashok
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  4. Avijit Guha
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  5. Vikas Sharma
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Correspondence to Aparna Mir.

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Nayar, S., Mir, A., Ashok, A. et al. Bovine serum albumin binding and drug delivery studies with PVA-ferrofluid. J Bionic Eng 7, 29–34 (2010). https://doi.org/10.1016/S1672-6529(09)60188-8

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