Abstract
Poly (vinyl alcohol)/hydroxylapatite (PVA/HA) composite hydrogel was prepared by repeated freezing and thawing. The water loss properties of the resultant hydrogel were investigated by using optical microscope. Long time immersion tests of PVA/HA composite hydrogel were carried out in the diluted calf serum solution to study the change laws of swelling properties with the freezing-thawing cycles and HA content. The micro-morphologies of PVA/HA composite hydrogel after long time immersion were observed by means of the high-accuracy 3D profiler. The results show that the swelling process of PVA/HA composite hydrogel is the converse process of its water loss. Long time swelling ratio curves of PVA/HA composite hydrogel in the calf serum solution are manifested as four stages of quick increase, decrease, slow decrease and stable balance, and its equilibrium swelling ratio decreases with the increase of freezing-thawing cycles and HA content. It is revealed that the network structure of the composite hydrogel immersed for a long period is significantly improved with the increase of HA content. Perfect network structures of PVA/HA composite hydrogel as well as full and equilibrium tissues after swelling equilibrium are obtained when the HA content is 3% and the number of freezing-thawing cycles is 7.
Similar content being viewed by others
References
Koba Y M, Toguchida J, Oka M. Preliminary study of polyvinyl alcohol/hydrogel (PVA/H) artificial meniscus. Biomaterials, 2003, 24, 639–647.
Swieszkowski W, Ku D N, Bersee H E N, Kurzydlowski K J. An elastic material for cartilage replacement in an arthritic shoulder joint. Biomaterials, 2006, 27, 1534–1541.
Stammen J A, Williams S, Ku D N, Guldberg R E. Mechanical properties of a novel PVA hydrogel in shear and unconfined compression. Biomaterials, 2001, 22, 799–806.
Spiller K L, Laurencin S J, Charlton D, Maher S A, Lowman A M. Superporous hydrogels for cartilage repair: Evaluation of the morphological and mechanical properties. Acta Biomaterialia, 2008, 4, 17–25.
Suciu A N, Iwatsubo T, Matsuda M. A study upon durability of the artificial knee joint with PVA hydrogel cartilage. JSME International Journal Series C, 2004, 47, 199–208.
Pan Y S, Xiong D S. Recent development on biotribology of poly (vinyl alcoho1) hydrogel. Tribology, 2006, 26, 188–192. (in Chinese)
Ji B, Gao J, Ma Y Z, Gu Z Q, Liu G Q, Xue H B. Manufacture of prosthetic nucleus and analysis of stressrelaxation properties. Journal of University of Science and Technology Beijing, 2005, 27, 589–592. (in Chinese)
Liu W G, Yao K D, Qi W Q. Advances in hydrogel. Polymer Materials Science and Engineering, 2002, 18, 54–57. (in Chinese)
Gu Z Q, Xiao J M, Zhang X H. Development of artificial articular cartilage-PVA hydrogel. Journal of Biomedical Engineering, 1999, 16, 13–18. (in Chinese)
Liu M Z, Cheng R S, Qian R Y. Investigation of swelling property of Poly (vinyl alcohol) hydrogel. Acta Polymerica Sinica, 1996, (2), 234–238. (in Chinese)
Huang C, Lu L, Qu D B, Zhang Z M, Jin D D. Preparation and swelling properties of pectin/poly (vinyl alcohol) composite hydrogel for prosthetic nucleus pulposus. Acta Materiae Compositae Sinica, 2008, 25, 69–75. (in Chinese)
Xu F L, Li Y B, Li J D, Mo Y H. Swelling properties of Nano-hydroxyaptite/polyvinyl alcohol hydrogel composite. Material Engineering, 2005, 7, 15–18. (in Chinese)
Park O O, Lee W S, Oh Y R, Han Y K. Quantitative analysis on swelling behavior of ionic gels in the mixed solvents. Korean Journal of Chemical Engineering, 1994, 11, 96–103.
Takigawa T, Kasihara H, Masuda T. Swelling and mechanical properties of polyvinylalcohol hydrogels. Polymer Bulletin, 1990, 24, 613–618.
Takigawa T, Uchida K, Takahashi K, Masuda T. Flow-induced swelling of poly (vinyl alcohol) gel. Journal of Chemical Physics, 1999, 111, 2295–2300.
Tong X, Zheng J J, Lu Y C, Zhang Z F, Cheng H M. Swelling and mechanical behaviors of carbon nanotube/poly (vinyl alcohol) hybrid hydrogels. Materials Letters, 2007, 61, 1704–1706.
Shen Y Q, Zhang D K, Ge S R. Research on the structure characterization and the biotribological behaviors of PVA/HA composite hydrogel. Chinese Journal of Materials Research, 2008, 22, 257–261. (in Chinese)
Zhang W, Li H Q, Yu H Y, Meng H M, Gu Z Q, Sun D B. Drying and swelling of PVA (Poly Vinyl Alcohol). Journal of University of Science and Technology Beijing, 2002, 24, 161–164. (in Chinese)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Zhang, Dk., Wang, Dg., Duan, Jj. et al. Research on the Long Time Swelling Properties of Poly (vinyl alcohol)/Hydroxylapatite Composite Hydrogel. J Bionic Eng 6, 22–28 (2009). https://doi.org/10.1016/S1672-6529(08)60093-1
Published:
Issue Date:
DOI: https://doi.org/10.1016/S1672-6529(08)60093-1